Department of Oral Pathology and Oral Biology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Head Neck Pathol. 2021 Dec;15(4):1415-1420. doi: 10.1007/s12105-021-01312-w. Epub 2021 Mar 11.
Primary mixed neuroendocrine-nonneuroendocrine neoplasm (MiNEN) of the head and neck region is a rare biphasic tumor with an aggressive biological behavior. This report highlights an additional case of oropharyngeal MiNEN in a 46-year-old male patient with a previous long-term smoking history. Histologic evaluation revealed a biphasic tumor infiltrating the lamina propria. The first component consisted of a classic keratinizing squamous cell carcinoma. The second component consisted of small-to-intermediate sized cells with neuroendocrine features. Synaptophysin and CD56 immunohistochemical stains confirmed neuroendocrine lineage in this component. The presence of two morphological components with neuroendocrine and nonneuroendocrine features on histologic assessment should alert the pathologist to consider a MiNEN in their case work-up.
头颈部的原发性混合神经内分泌-非神经内分泌肿瘤（MiNEN）是一种罕见的具有侵袭性生物学行为的双相肿瘤。本报告强调了一例 46 岁男性患者的口咽 MiNEN 病例，该患者有长期吸烟史。组织学评估显示，肿瘤侵犯固有层呈双相性。第一部分由经典角化鳞状细胞癌组成。第二部分由具有神经内分泌特征的小至中等大小细胞组成。突触素和 CD56 免疫组化染色证实了该成分的神经内分泌谱系。在组织学评估中，如果存在具有神经内分泌和非神经内分泌特征的两种形态成分，病理医生应该警惕在他们的病例工作中考虑 MiNEN。
