口咽部混合性神经内分泌-非神经内分泌肿瘤（MiNEN）：病例报告及文献复习。
Oropharyngeal Mixed Neuroendocrine-Nonneuroendocrine Neoplasm (MiNEN): A Case Report and Literature Review.
机构信息
Department of Oral Pathology and Oral Biology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
出版信息
Head Neck Pathol. 2021 Dec;15(4):1415-1420. doi: 10.1007/s12105-021-01312-w. Epub 2021 Mar 11.
Abstract
Primary mixed neuroendocrine-nonneuroendocrine neoplasm (MiNEN) of the head and neck region is a rare biphasic tumor with an aggressive biological behavior. This report highlights an additional case of oropharyngeal MiNEN in a 46-year-old male patient with a previous long-term smoking history. Histologic evaluation revealed a biphasic tumor infiltrating the lamina propria. The first component consisted of a classic keratinizing squamous cell carcinoma. The second component consisted of small-to-intermediate sized cells with neuroendocrine features. Synaptophysin and CD56 immunohistochemical stains confirmed neuroendocrine lineage in this component. The presence of two morphological components with neuroendocrine and nonneuroendocrine features on histologic assessment should alert the pathologist to consider a MiNEN in their case work-up.
摘要
头颈部的原发性混合神经内分泌-非神经内分泌肿瘤（MiNEN）是一种罕见的具有侵袭性生物学行为的双相肿瘤。本报告强调了一例 46 岁男性患者的口咽 MiNEN 病例，该患者有长期吸烟史。组织学评估显示，肿瘤侵犯固有层呈双相性。第一部分由经典角化鳞状细胞癌组成。第二部分由具有神经内分泌特征的小至中等大小细胞组成。突触素和 CD56 免疫组化染色证实了该成分的神经内分泌谱系。在组织学评估中，如果存在具有神经内分泌和非神经内分泌特征的两种形态成分，病理医生应该警惕在他们的病例工作中考虑 MiNEN。
相似文献
1
Oropharyngeal Mixed Neuroendocrine-Nonneuroendocrine Neoplasm (MiNEN): A Case Report and Literature Review.口咽部混合性神经内分泌-非神经内分泌肿瘤（MiNEN）：病例报告及文献复习。
Head Neck Pathol. 2021 Dec;15(4):1415-1420. doi: 10.1007/s12105-021-01312-w. Epub 2021 Mar 11.
2
Oropharyngeal Mixed Neuroendocrine-Nonneuroendocrine Neoplasm (MiNEN): A Case Report and Literature Review.口咽部混合性神经内分泌-非神经内分泌肿瘤（MiNEN）：病例报告及文献复习。
Head Neck Pathol. 2024 Jun 19;18(1):53. doi: 10.1007/s12105-024-01660-3.
3
Mixed Adenoma Well-differentiated Neuroendocrine Tumor (MANET) of the Digestive System: An Indolent Subtype of Mixed Neuroendocrine-NonNeuroendocrine Neoplasm (MiNEN).消化系统混合性腺瘤-神经内分泌肿瘤（MANET）：一种惰性混合性神经内分泌-非神经内分泌肿瘤（MiNEN）亚型。
Am J Surg Pathol. 2018 Nov;42(11):1503-1512. doi: 10.1097/PAS.0000000000001123.
4
Mixed neuroendocrine nonneuroendocrine neoplasms of the pancreas: a case report and literature review of pancreatic mixed neuroendocrine nonneuroendocrine neoplasm.胰腺混合性神经内分泌-非神经内分泌肿瘤：一例胰腺混合性神经内分泌-非神经内分泌肿瘤病例报告及文献复习
Gland Surg. 2021 Dec;10(12):3443-3452. doi: 10.21037/gs-21-564.
5
Mixed Neuroendocrine-Nonneuroendocrine Neoplasms (MiNENs): Unifying the Concept of a Heterogeneous Group of Neoplasms.混合性神经内分泌-非神经内分泌肿瘤（MiNENs）：统一一组异质性肿瘤的概念
Endocr Pathol. 2016 Dec;27(4):284-311. doi: 10.1007/s12022-016-9432-9.
6
Presentation and outcome of mixed neuroendocrine non-neuroendocrine neoplasms of the pancreas.胰腺混合性神经内分泌-非神经内分泌肿瘤的临床表现及转归
Pancreatology. 2021 Jan;21(1):224-235. doi: 10.1016/j.pan.2020.11.020. Epub 2020 Dec 3.
7
Does Mixed Neuroendocrine-Nonneuroendocrine Neoplasm (MiNEN) of the Parathyroid Gland Exist? First Description of a Possible Case.甲状旁腺混合神经内分泌-非神经内分泌肿瘤（MiNEN）是否存在？首例疑似病例的描述。
Head Neck Pathol. 2021 Mar;15(1):381-387. doi: 10.1007/s12105-020-01178-4. Epub 2020 Jun 6.
8
Clinicopathologic and Molecular Characterization of Inflammatory Bowel Disease-Associated Neuroendocrine Carcinomas and Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms.炎症性肠病相关神经内分泌癌和混合性神经内分泌-非神经内分泌肿瘤的临床病理和分子特征。
Mod Pathol. 2024 Oct;37(10):100566. doi: 10.1016/j.modpat.2024.100566. Epub 2024 Jul 16.
9
Mixed Intraepithelial Neoplasia-Well-Differentiated Neuroendocrine Tumor of the Gallbladder: A Hitherto Unreported Combination.胆囊混合上皮内瘤-高分化神经内分泌肿瘤：一种迄今尚未报道的组合。
Int J Surg Pathol. 2021 Sep;29(6):685-689. doi: 10.1177/1066896920986987. Epub 2021 Jan 9.
10
Mixed neuroendocrine-nonneuroendocrine neoplasms of the gastrointestinal system: An update.消化系统混合性神经内分泌-非神经内分泌肿瘤：最新进展。
World J Gastroenterol. 2022 Feb 28;28(8):794-810. doi: 10.3748/wjg.v28.i8.794.
引用本文的文献
1
Oropharyngeal Mixed Neuroendocrine-Nonneuroendocrine Neoplasm (MiNEN): A Case Report and Literature Review.口咽部混合性神经内分泌-非神经内分泌肿瘤（MiNEN）：病例报告及文献复习。
Head Neck Pathol. 2024 Jun 19;18(1):53. doi: 10.1007/s12105-024-01660-3.
2
Ureter mixed neuroendocrine-non-neuroendocrine neoplasm: a case report and literature review.输尿管混合性神经内分泌-非神经内分泌肿瘤：一例报告及文献复习
Front Oncol. 2024 May 31;14:1390350. doi: 10.3389/fonc.2024.1390350. eCollection 2024.
3
Primary Oral Mixed Neuroendocrine-Non-neuroendocrine Neoplasm (MiNEN): A Rare Case Report and Review of the Literature.原发性口腔混合性神经内分泌-非神经内分泌肿瘤（MiNEN）：一例罕见病例报告及文献复习。
Head Neck Pathol. 2024 Feb 23;18(1):13. doi: 10.1007/s12105-024-01613-w.
4
Human papillomavirus status and prognosis of oropharyngeal high-grade neuroendocrine carcinoma.人乳头瘤病毒状态与口咽高级别神经内分泌癌的预后
Oral Oncol. 2023 Mar;138:106311. doi: 10.1016/j.oraloncology.2023.106311. Epub 2023 Jan 24.
5
Long-term survival of gastric mixed neuroendocrine-non-neuroendocrine neoplasm: Two case reports.胃神经内分泌-非神经内分泌混合性肿瘤的长期生存：两例报告
World J Clin Cases. 2022 Aug 6;10(22):7936-7943. doi: 10.12998/wjcc.v10.i22.7936.
6
Combined large cell neuroendocrine carcinoma and squamous cell carcinoma of the oropharynx: A collision course of tumors.口咽合并大细胞神经内分泌癌和鳞状细胞癌：肿瘤的碰撞过程。
Clin Case Rep. 2022 Jan 27;10(1):e05319. doi: 10.1002/ccr3.5319. eCollection 2022 Jan.
7
Neuroendocrine Carcinoma of the Larynx and Pharynx: A Clinical and Histopathological Study.喉咽神经内分泌癌：一项临床与组织病理学研究
Cancers (Basel). 2021 Sep 27;13(19):4813. doi: 10.3390/cancers13194813.
本文引用的文献
1
A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal.神经内分泌肿瘤的通用分类框架：国际癌症研究机构（IARC）和世界卫生组织（WHO）专家共识建议。
Mod Pathol. 2018 Dec;31(12):1770-1786. doi: 10.1038/s41379-018-0110-y. Epub 2018 Aug 23.
2
Neuroendocrine Carcinomas of the Larynx and Head and Neck: Challenges in Classification and Grading.喉及头颈部神经内分泌癌：分类与分级面临的挑战
Head Neck Pathol. 2018 Mar;12(1):1-8. doi: 10.1007/s12105-018-0894-6. Epub 2018 Mar 20.
3
Primary combined small cell carcinoma and squamous cell carcinoma of the oropharynx with special reference to EGFR status of small cell carcinoma component: Case report and review of the literature.原发性口咽小细胞癌合并鳞状细胞癌，特别关注小细胞癌成分的表皮生长因子受体（EGFR）状态：病例报告及文献复习
Auris Nasus Larynx. 2017 Aug;44(4):472-478. doi: 10.1016/j.anl.2016.07.011. Epub 2016 Aug 3.
4
p16 overexpression in high-grade neuroendocrine carcinomas of the head and neck: potential diagnostic pitfall with HPV-related carcinomas.头颈部高级别神经内分泌癌中p16过表达：与HPV相关癌的潜在诊断陷阱
Virchows Arch. 2016 Sep;469(3):277-84. doi: 10.1007/s00428-016-1982-1. Epub 2016 Jul 8.
5
Mixed Neuroendocrine-Nonneuroendocrine Neoplasms (MiNENs): Unifying the Concept of a Heterogeneous Group of Neoplasms.混合性神经内分泌-非神经内分泌肿瘤（MiNENs）：统一一组异质性肿瘤的概念
Endocr Pathol. 2016 Dec;27(4):284-311. doi: 10.1007/s12022-016-9432-9.
6
Primary combined neuroendocrine and squamous cell carcinoma of the maxillary sinus: report of a case with immunohistochemical and molecular characterization.上颌窦原发性神经内分泌与鳞状细胞联合癌：1例免疫组化及分子特征报告
Head Neck Pathol. 2015 Mar;9(1):107-13. doi: 10.1007/s12105-013-0513-5. Epub 2013 Dec 11.
7
Colliding tumor of the paranasal sinus.鼻窦碰撞瘤
Allergy Rhinol (Providence). 2013 Spring;4(1):e13-6. doi: 10.2500/ar.2013.4.0040.
8
Mixed exocrine-neuroendocrine carcinoma of the nasal cavity: clinico-pathologic and molecular study of a case and review of the literature.鼻腔混合性外分泌-神经内分泌癌：1例临床病理及分子研究并文献复习
Head Neck Pathol. 2013 Mar;7(1):76-84. doi: 10.1007/s12105-012-0379-y. Epub 2012 Jun 28.
9
Human papillomavirus-related small cell carcinoma of the oropharynx.人乳头瘤病毒相关口咽小细胞癌。
Am J Surg Pathol. 2011 Nov;35(11):1679-84. doi: 10.1097/PAS.0b013e3182299cde.
10
Expression of p16 in sinonasal undifferentiated carcinoma (SNUC) without associated human papillomavirus (HPV).p16在无相关人乳头瘤病毒（HPV）的鼻窦未分化癌（SNUC）中的表达。
Head Neck Pathol. 2011 Dec;5(4):349-54. doi: 10.1007/s12105-011-0285-8. Epub 2011 Jul 30.
Zotero 插件