Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, USA.
Department of Otolaryngology/Head and Neck Surgery, University of North Carolina, Chapel Hill, USA.
Head Neck Pathol. 2024 Jun 19;18(1):53. doi: 10.1007/s12105-024-01660-3.
Mixed neuroendocrine-nonneuroendocrine (MiNEN) neoplasms in the head and neck are exceptionally rare biphasic tumors with unclear pathogenesis and an aggressive clinical behavior. This is the first reported case of an oropharyngeal MiNEN with the nonneuroendocrine component being an HPV-associated adenocarcinoma. The tumor arose in a 56 year-old male with history of long-term cigarette smoking and was composed of an adenocarcinoma intermixed with a small cell neuroendocrine carcinoma. P16 immunohistochemical stain and HPV16/18 in-situ hybridization were strongly and diffusely expressed in both components.
头颈部混合性神经内分泌-非神经内分泌（MiNEN）肿瘤是一种极为罕见的双相性肿瘤，其发病机制尚不清楚，且临床表现具有侵袭性。这是首例报道的口咽部 MiNEN 病例，其中非神经内分泌成分为 HPV 相关的腺癌。该肿瘤发生于一名 56 岁男性，有长期吸烟史，由腺癌与小细胞神经内分泌癌混合而成。两种成分均强阳性且弥漫表达 P16 免疫组化染色和 HPV16/18 原位杂交。
