用于生物学评估的棉酚对映体的大规模拆分

Large-scale resolution of gossypol enantiomers for biological evaluation.

作者信息

Matlin S A, Zhou R H, Belenguer A, Tyson R G, Brookes A N

机构信息

Chemistry Department, The City University, London, UK.

出版信息

Contraception. 1988 Mar;37(3):229-37. doi: 10.1016/0010-7824(88)90025-x.

DOI:10.1016/0010-7824(88)90025-x

PMID:3370995

Abstract

Gossypol has been resolved into its pure optical isomers by conversion into the Schiff's base derivative of (+)-phenylalanine methyl ester, normal or reverse phase chromatography and hydrolysis. Forty grams of pure (-)-gossypol has been prepared in a micronised form for assessment of its antifertility and toxicological effects.

摘要

通过转化为（+）-苯丙氨酸甲酯的席夫碱衍生物、正相或反相色谱法以及水解，棉酚已被拆分为其纯光学异构体。已制备出40克微粉化形式的纯（-）-棉酚，用于评估其抗生育和毒理学效应。