Matlin S A, Zhou R, Bialy G, Blye R P, Naqvi R H, Lindberg M C
Contraception. 1985 Feb;31(2):141-9. doi: 10.1016/0010-7824(85)90027-7.
The enantiomers of gossypol have been resolved by preparative HPLC of diastereomeric Schiff's base derivatives on a chiral bonded phase. Whereas (+)-gossypol has previously been reported to be inactive, (-)-gossypol is now shown to be active as a male oral antifertility agent in hamsters.
