Tennessee Retina, Nashville, Tennessee.
Oregon Health and Science University, Portland, Oregon, USA.
Curr Opin Ophthalmol. 2021 May 1;32(3):169-182. doi: 10.1097/ICU.0000000000000762.
Given the heterogeneity of uveitis, markers of inflammation vary from patient to patient. Multimodal imaging has proven itself to be critical for accurate evaluation for disease activity and treatment response in uveitis.
Ultra-widefield (UWF) fluorescein angiography and autofluorescence (AF) as well as optical coherence tomography angiography (OCTA) have provided insights into disease pathogenesis and monitoring not previously appreciated. In addition to structural retinal imaging, OCT can be used to assess the choroid, the posterior cortical vitreous and the retinal vasculature in eyes with uveitis.
Multimodal ocular imaging in eyes with uveitis is critical for disease diagnosis and assessing response to treatment. UWF fluorescein angiography can detect retinal vasculitis even in the absence of overt vascular sheathing. UWF AF can help detect more chorioretinal lesions than clinically visible. OCT can be used to assess the posterior cortical vitreous, retina, large retinal vessels and choroid in uveitis. The use of multimodal imaging will likely be needed to determine clinical trial endpoints in studies evaluating therapeutics for uveitis.
鉴于葡萄膜炎的异质性，炎症标志物因患者而异。多模态成像已被证明对准确评估葡萄膜炎的疾病活动度和治疗反应至关重要。
超广角（UWF）荧光素血管造影和自发荧光（AF）以及光相干断层扫描血管造影（OCTA）为疾病发病机制和监测提供了以前未被认识到的见解。除了结构视网膜成像外，OCT 还可用于评估葡萄膜炎眼的脉络膜、后皮质玻璃体和视网膜血管。
葡萄膜炎眼的多模态眼部成像对于疾病诊断和评估治疗反应至关重要。超广角荧光素血管造影甚至可以在没有明显血管鞘的情况下检测视网膜血管炎。超广角 AF 可以帮助发现比临床可见的更多的脉络膜视网膜病变。OCT 可用于评估葡萄膜炎眼中的后皮质玻璃体、视网膜、大视网膜血管和脉络膜。在评估葡萄膜炎治疗药物的临床试验中，可能需要使用多模态成像来确定临床试验终点。
