Department of Ophthalmology, Faculty of Medicine, Başkent University, Ankara, Turkey.
Department of Ophthalmology, Faculty of Medicine, Başkent University, İstanbul, Turkey.
Indian J Ophthalmol. 2023 Jan;71(1):153-160. doi: 10.4103/ijo.IJO_1298_22.
To evaluate the macular microvascular changes in patients with intermediate uveitis (IU) using optical coherence tomography angiography (OCT-A) and to determine the relationship of OCT-A measurements with disease duration and activity.
This cross-sectional study was performed at the uvea department of a tertiary hospital. Patients with IU (8 women, 8 men; mean age: 28.80 ± 12.80 years) were included in the study. The macular thickness measurements obtained by optical coherence tomography (OCT) (Heidelberg Spectralis, Heidelberg Engineering, Heidelberg, Germany) and macular superficial and deep vessel density (VD) parameters obtained by OCT-A (Avanti RTVue-XR; Optovue, Fremont, CA, USA) were compared with healthy subjects (12 men, 22 women; mean age: 28.40 ± 8.32 years). Eyes with pathology including marked obvious edema in the macula were not included in the study.
The macular thickness was found to be higher in the patient group (p < 0.001). The deep and superficial VD measurements in almost all quadrants in both superficial and deep layers were significantly lower in the IU patient group (p < 0.05). Macular thickness was increased in the active state of IU (p = 0.03), however, none of the OCT-A parameters showed a significant difference between active and inactive IU patients (p > 0.05). No correlation was observed between OCT-A parameters and total IU disease duration.
Quantitative analyses of macular vascular structures demonstrate significantly reduced VD in both superficial and deep retinal layers in IU patients. Considering the importance of the macula in visual prognosis, OCT-A can provide crucial data for the monitoring and follow-up of IU patients.
利用光相干断层扫描血管造影术（OCT-A）评估中间葡萄膜炎（IU）患者的黄斑微血管变化，并确定 OCT-A 测量值与疾病持续时间和活动的关系。
本横断面研究在一家三级医院的葡萄膜科进行。纳入 IU 患者（8 名女性，8 名男性；平均年龄：28.80±12.80 岁）。比较光学相干断层扫描（OCT）（德国海德堡光谱仪，海德堡工程公司，海德堡）获得的黄斑厚度测量值和 OCT-A（Avanti RTVue-XR；Optovue，弗里蒙特，CA，美国）获得的黄斑浅层和深层血管密度（VD）参数与健康受试者（12 名男性，22 名女性；平均年龄：28.40±8.32 岁）。未纳入研究的眼部包括黄斑区有明显明显水肿的病变眼。
发现患者组的黄斑厚度较高（p<0.001）。在浅层和深层的几乎所有象限中，深层和浅层的 VD 测量值在 IU 患者组中均显著降低（p<0.05）。IU 的活动状态下黄斑厚度增加（p=0.03），然而，OCT-A 参数在活动和不活动 IU 患者之间无显著差异（p>0.05）。OCT-A 参数与 IU 总病程之间无相关性。
黄斑血管结构的定量分析显示 IU 患者的浅层和深层视网膜 VD 均显著降低。考虑到黄斑在视觉预后中的重要性，OCT-A 可为 IU 患者的监测和随访提供关键数据。
