MOE Key Laboratory for Analytical Science of Food Safety and Biology; Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety; State Key Laboratory of Photocatalysis on Energy and Environment College of Chemistry, Fuzhou, Fujian 350116, P. R. China.
Nanoscale. 2021 Mar 21;13(11):5817-5825. doi: 10.1039/d1nr00132a. Epub 2021 Mar 12.
Photothermal therapy (PTT) has been extensively used as an effective therapeutic approach against cancer. However, PTT can trigger the proinflammatory response of dendritic cells (DCs) and macrophages to release proinflammatory cytokines, which can simulate tumor regeneration and further hinder subsequent therapy. Hence, an effective therapeutic system, comprising gold nanoparticle modified CuZnSnS nanocrystals and aspirin (Au-CZTS/Asp), was developed to co-deliver PTT agents and inflammatory inhibitors for the synergistic treatment of cancer. Au-CZTS with high near infrared (NIR) photothermal conversion abilities can effectively induce apoptosis and tumor ablation under NIR light. Furthermore, Asp can inhibit the activation of the cGAS-STING pathway in DCs and the polarization of macrophages to intercept the PTT mediated inflammatory responses. Therefore, the as-prepared Au-CZTS/Asp can effectively realize the integration of tumor treatment and recovery. Simultaneously, the Au-CZTS/Asp with ultrasmall size can be rapidly cleared to reduce biotoxicity and side effects. In addition, the Au-CZTS/Asp showed excellent photoacoustic (PA) imaging properties around the tumor in vivo. Thus, our study provides a potential platform for a nano-prodrug that is viable for cancer diagnostic-treatment-recovery integration.
光热疗法（PTT）已被广泛应用于癌症的有效治疗方法。然而，PTT 可以触发树突状细胞（DCs）和巨噬细胞的促炎反应，释放促炎细胞因子，这可能模拟肿瘤再生，并进一步阻碍后续治疗。因此，开发了一种有效的治疗系统，包括金纳米颗粒修饰的 CuZnSnS 纳米晶体和阿司匹林（Au-CZTS/Asp），用于协同治疗癌症的递药和炎症抑制剂。具有高近红外（NIR）光热转换能力的 Au-CZTS 可以在 NIR 光下有效诱导细胞凋亡和肿瘤消融。此外，Asp 可以抑制 DCs 中的 cGAS-STING 通路的激活和巨噬细胞的极化，从而阻断 PTT 介导的炎症反应。因此，所制备的 Au-CZTS/Asp 可以有效地实现肿瘤治疗和恢复的整合。同时，具有超小尺寸的 Au-CZTS/Asp 可以迅速清除，以减少生物毒性和副作用。此外，Au-CZTS/Asp 在体内肿瘤周围表现出优异的光声（PA）成像性能。因此，我们的研究为癌症诊断-治疗-恢复整合的纳米前药提供了一个有前途的平台。
