Laboratory of Controllable Preparation and Application of Nanomaterials, State Key Laboratory of Technologies in Space Cryogenic Propellants, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, No.29 East Road Zhongguancun, Beijing, 100190, PR China.
College of Chemistry & Environment Protection Engineering, Southwest Minzu University, Chengdu, 610041, PR China.
Biomaterials. 2018 Mar;159:108-118. doi: 10.1016/j.biomaterials.2018.01.003. Epub 2018 Jan 2.
Ultrasmall CuZnSnS (CZTS) nanocrystals with high near infrared (NIR) photothermal conversion abilities and peroxidase-mimic properties are synthesized and functionalized with bovine serum albumin (BSA) for rapid clearance multifunctional theranostic platform. Due to the presence of Cu (I) of CZTS@BSA, HO could be decomposed to produce highly reactive oxygen species (ROS), catalyzed by intrinsic peroxidase like activity of CZTS. The CZTS@BSA possesses high NIR absorption and excellent photoacoustic (PA) imaging abilities. The as-prepared CZTS@BSA is also reported as an efficient T1 contrast agent for in vivo MR imaging. Therefore, in vivo distribution and rapid renal clearance of CZTS@BSA are successfully tracked by PA/MR dual-modal-imaging and further proved by ICP-MS analysis. Systemic acute toxicity evaluation indicates CZTS@BSA have good biocompatibility to normal tissues and blood. All results reveal that CZTS@BSA could act as a rapid clearance theranostic nanoplatform for dual-modal-imaging guided tumor PTT.
具有高光热转换能力和过氧化物酶模拟特性的超小 CuZnSnS（CZTS）纳米晶体被合成并功能化与牛血清白蛋白（BSA）结合，以构建快速清除多功能治疗平台。由于 CZTS@BSA 中存在 Cu（I），HO 可以被分解以产生高反应性氧物质（ROS），这是由 CZTS 的固有过氧化物酶样活性催化的。CZTS@BSA 具有高近红外（NIR）吸收和优异的光声（PA）成像能力。所制备的 CZTS@BSA 也被报道为用于体内磁共振成像的高效 T1 造影剂。因此，通过 PA/MR 双模态成像成功跟踪了 CZTS@BSA 的体内分布和快速肾清除，并通过 ICP-MS 分析进一步证实。系统急性毒性评估表明 CZTS@BSA 对正常组织和血液具有良好的生物相容性。所有结果表明，CZTS@BSA 可作为用于双模态成像引导肿瘤 PTT 的快速清除治疗纳米平台。
