Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha Hunan, 410082, China.
College of Life Sciences, Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chem/Bio-Sencing and Chemometrics, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha Hunan, 410082, China.
Angew Chem Int Ed Engl. 2018 Jan 2;57(1):177-181. doi: 10.1002/anie.201709648. Epub 2017 Dec 5.
Photothermal therapy (PTT) has been extensively developed as an effective approach against cancer. However, PTT can trigger inflammatory responses, in turn simulating tumor regeneration and hindering subsequent therapy. A therapeutic strategy was developed to deliver enhanced PTT and simultaneously inhibit PTT-induced inflammatory response. 1-Pyrene methanol was utilize to synthesize the anti-inflammatory prodrug pyrene-aspirin (P-aspirin) with a cleavable ester bond and also facilitate loading the prodrug on gold nanorod (AuNR)-encapsulated graphitic nanocapsule (AuNR@G), a photothermal agent, through π-π interactions. Such AuNR@G-P-aspirin complexes were used for near-infrared laser-triggered photothermal ablation of solid tumor and simultaneous inhibition of PTT-induced inflammation through the release of aspirin in tumor milieu. This strategy showed excellent effects in vitro and in vivo.
光热疗法（PTT）已被广泛开发为一种有效的抗癌方法。然而，PTT 会引发炎症反应，从而模拟肿瘤再生并阻碍后续治疗。开发了一种治疗策略，以提供增强的 PTT 并同时抑制 PTT 诱导的炎症反应。1-芘甲醇被用于合成具有可裂解酯键的抗炎前药芘-阿司匹林（P-阿司匹林），并通过 π-π 相互作用促进将前药装载到金纳米棒（AuNR）封装的石墨纳米胶囊（AuNR@G）上，这是一种光热试剂。通过在肿瘤微环境中释放阿司匹林，这种 AuNR@G-P-aspirin 复合物用于近红外激光触发的实体瘤光热消融和同时抑制 PTT 诱导的炎症。该策略在体外和体内均显示出优异的效果。
