Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Brazil.
Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Brazil.
Int J Exp Pathol. 2021 Apr;102(2):74-79. doi: 10.1111/iep.12387. Epub 2021 Mar 12.
Hypercholesterolaemia is a complex condition with multiple causes, including both lifestyle and genetic aspects. It is also a risk factor for cardiovascular diseases (CVDs), which are responsible for 172 million deaths/year. Although the reasons for hypercholesterolaemia are known, there are many critical questions that remain to be answered so that new therapeutics can be developed. In order to elucidate the pathobiology of this condition, animal models can mimic the pathology of human hypercholesterolaemia. One example of an animal model is induced by the hypercholesterolaemic diet in Wistar rats. The present review first summarizes the current understanding of the metabolic profile involved in hypercholesterolaemia in humans. Next it comments about the lack of consensus as to which hypercholesterolaemia induction protocol should be used. The present work aimed to review experimental studies that induced hypercholesterolaemia in Wistar rats it was not intended to judge the "best" model, since they all achieved the goal of inducing an increase in serum cholesterol.
高胆固醇血症是一种复杂的病症，其病因既有生活方式因素，也有遗传因素。它也是心血管疾病（CVDs）的一个风险因素，每年导致 1.72 亿人死亡。尽管高胆固醇血症的原因已经被了解，但仍有许多关键问题有待回答，以便开发新的治疗方法。为了阐明这种疾病的病理生物学，动物模型可以模拟人类高胆固醇血症的病理学。一个动物模型的例子是通过在 Wistar 大鼠中使用高胆固醇饮食来诱导的。本综述首先总结了目前对人类高胆固醇血症中涉及的代谢谱的理解。接下来，它评论了关于应该使用哪种高胆固醇血症诱导方案缺乏共识的问题。本工作旨在综述诱导 Wistar 大鼠高胆固醇血症的实验研究，其目的不是判断“最佳”模型，因为它们都实现了诱导血清胆固醇升高的目标。
