Santos-López Jorge Arturo, Garcimartín Alba, López-Oliva María Elvira, Bautista-Ávila Mirandeli, González-Muñoz María José, Bastida Sara, Benedí Juana, Sánchez-Muniz Francisco José
1 Pharmacology Department, Pharmacy School, Complutense University of Madrid, Madrid, Spain .
2 Nutrition and Food Science Department I (Nutrition), Pharmacy School, Complutense University of Madrid, Madrid, Spain .
J Med Food. 2017 May;20(5):526-534. doi: 10.1089/jmf.2016.0161. Epub 2017 Mar 15.
Chia oil has the highest recognized α-linolenic acid (ALA) content. ALA is associated with beneficial changes in plasma lipids and the prevention of cardiovascular diseases. Present article aims to analyze the effect of Chia oil-enriched restructured pork (RP) on aged rats in a nonalcoholic steatohepatitis (NASH) model. Groups of six male Wistar rats (1-year old) were fed the experimental diets: control RP diet (C) noncholesterol high saturated; cholesterol-enriched high-saturated fat/high-cholesterol control RP diet (HC) with added cholesterol and cholic acid; and Chia oil- or Hydroxytyrosol RP cholesterol-enriched high-saturated fat/high cholesterol (CHIA and HxT). Total cholesterol, hepatosomatic index, Nrf2, antioxidant, and inflammation markers were determined. CHIA reduced the hypercholesterolemic effect by lowering levels similar to C; also, ameliorated redox index. CHIA, despite high polyunsaturated fatty acids (PUFA) content, reduced thiobarbituric acid reactive substances (TBARS) and induced the lowest SOD protein synthesis but not a reduction on its activity. Chia oil activated the Nrf2 to arrest the pro-oxidative response to cholesterol and aging. Endothelial nitric oxide synthase (eNOS) system was lower in HxT than in CHIA, suggesting its antiatherogenic activity and related protective effect against high PUFA. Increase in tumor necrosis factor alpha (TNFα) was partially blocked by CHIA. Chia oil has the ability to prevent oxidative damage and modify the inflammatory response, suggesting adequate regulation of the antioxidant system. Results stress the importance of incorporating ALA into the diet.
奇亚籽油具有公认的最高α-亚麻酸（ALA）含量。ALA与血浆脂质的有益变化以及心血管疾病的预防有关。本文旨在分析富含奇亚籽油的重组猪肉（RP）对非酒精性脂肪性肝炎（NASH）模型老年大鼠的影响。将六组雄性Wistar大鼠（1岁）喂食实验性饮食：对照RP饮食（C），非胆固醇高饱和；富含胆固醇的高饱和脂肪/高胆固醇对照RP饮食（HC），添加了胆固醇和胆酸；以及奇亚籽油或羟基酪醇RP胆固醇丰富的高饱和脂肪/高胆固醇（CHIA和HxT）。测定总胆固醇、肝体指数、Nrf2、抗氧化剂和炎症标志物。CHIA通过降低与C相似的水平降低了高胆固醇血症效应；此外，改善了氧化还原指数。尽管CHIA含有高含量的多不饱和脂肪酸（PUFA），但它降低了硫代巴比妥酸反应性物质（TBARS），并诱导了最低的超氧化物歧化酶（SOD）蛋白合成，但并未降低其活性。奇亚籽油激活了Nrf2，以阻止对胆固醇和衰老的促氧化反应。羟基酪醇组（HxT）的内皮型一氧化氮合酶（eNOS）系统低于奇亚籽油组（CHIA），表明其抗动脉粥样硬化活性以及对高PUFA的相关保护作用。肿瘤坏死因子α（TNFα）的增加被CHIA部分阻断。奇亚籽油有能力预防氧化损伤并改变炎症反应，表明对抗氧化系统有适当的调节作用。结果强调了将ALA纳入饮食的重要性。
