多民族、社区为基础的痴呆老年人样本中的锥体外系体征与阿尔茨海默病预后。
Extrapyramidal signs and Alzheimer's disease prognosis in a multiethnic, community-based sample of demented elders.
机构信息
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Department of Biostatistics, Columbia University, New York, New York, USA.
出版信息
Alzheimers Dement. 2021 Sep;17(9):1465-1473. doi: 10.1002/alz.12309. Epub 2021 Mar 12.
INTRODUCTION
Extrapyramidal signs (EPS) are a common feature of Alzheimer's disease associated with worse outcomes in observational studies of dementia. Less research has been conducted on ethnic minority and non-clinic-based populations.
METHODS
One hundred and forty-two multiethnic community-dwelling participants with dementia were selected. Adjusted Cox models were fitted for mortality, cognitive (Mini Mental State Examination ≤10), functional (Blessed Dementia Rating Scale ≥10), and dependency (needs full-time care) endpoints with baseline EPS as predictor.
RESULTS
Thirty-seven participants (26.06%) had EPS at baseline. EPS predicted more rapid time to death (hazard ratio [HR] = 2.76, 95% confidence interval [CI] = 1.49, 5.42), and functional endpoint (HR = 3.88, 95% CI = 1.75, 8.62) but not cognitive and dependency endpoints. No evidence of interaction by ethnicity, age, sex, education, or apolipoprotein E ε4 polymorphism was found.
DISCUSSION
Our results partially confirm previous studies on predominantly White, clinic-based samples. Further research is needed to better understand the etiological role of EPS in AD.
简介
锥体外系症状（EPS）是与痴呆观察研究中较差结局相关的阿尔茨海默病的常见特征。针对少数民族和非临床人群的研究较少。
方法
选择了 142 名多民族社区居住的痴呆症患者。使用调整后的 Cox 模型对死亡率、认知（简易精神状态检查≤10）、功能（Blessed 痴呆评定量表≥10）和依赖（需要全职护理）终点进行了基线 EPS 预测因子的拟合。
结果
37 名参与者（26.06%）基线时存在 EPS。EPS 预测死亡时间更快（风险比[HR]=2.76，95%置信区间[CI]=1.49，5.42），功能终点（HR=3.88，95%CI=1.75，8.62），但不预测认知和依赖终点。未发现种族、年龄、性别、教育程度或载脂蛋白 E ε4 多态性的交互作用证据。
讨论
我们的结果部分证实了以前主要针对白人、临床样本的研究。需要进一步研究以更好地了解 EPS 在 AD 中的病因作用。
Zotero 插件