Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, RenJi Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Clinical Biochemistry Laboratory, RenJi Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
PLoS One. 2021 Mar 12;16(3):e0248427. doi: 10.1371/journal.pone.0248427. eCollection 2021.
BACKGROUND & AIMS: Helicobacter pylori (H. pylori) infection remains high in China though the incidence of inflammatory bowel disease (IBD) has increased. Our aim was to investigate the relationship between the prevalence of H. pylori and inflammatory bowel disease.
Hospitalized IBD patients including Crohn's disease (CD) and ulcerative colitis (UC) who had tested H. pylori antibody were enrolled. Controls were chose from age- and sex- matched healthy physical examination people who had H. pylori antibody test in a 1:2 fashion (IBD patients:controls). IBD medical history was recorded. All patients were typed by the Montreal classification. Mayo Clinic score and the Harvey-Bradshaw Severity Index were used to evaluate their disease activity. Patients and controls that had H. pylori eradication therapy before were excluded.
Two hundred and sixty IBD patients including 213 CD patients and 47 UC patients, and 520 controls were involved in this study. The prevalence of H. pylori infection in IBD patients (9.6%, 25/260) and IBD newly diagnosed patients (12.1%, 8/66), as well as CD patients (8.9%, 19/213) including CD newly diagnosed patients (10.6%, 5/47) and UC patients (12.8%, 6/47) was significantly lower than controls (29.8%, 155/520) (p = 2.79610-10, 0.007, 5.72310-9, 0.016, 0.014), while there was no statistically difference between UC newly diagnosed patients and the controls, and IBD patients with different disease type, disease activity and treatment history.
H. pylori infection had a negative association with IBD, especially CD.
尽管炎症性肠病（IBD）的发病率有所增加，但中国的幽门螺杆菌（H. pylori）感染仍然很高。本研究旨在探讨 H. pylori 感染与炎症性肠病之间的关系。
纳入了接受 H. pylori 抗体检测的住院 IBD 患者，包括克罗恩病（CD）和溃疡性结肠炎（UC）患者。按照 1:2 的比例选择年龄和性别匹配的健康体检人群作为对照（IBD 患者：对照），这些人也接受了 H. pylori 抗体检测。记录 IBD 病史。所有患者均采用蒙特利尔分类进行分型。采用 Mayo 评分和 Harvey-Bradshaw 严重程度指数评估疾病活动度。排除了接受 H. pylori 根除治疗的患者和对照。
本研究共纳入 260 例 IBD 患者（213 例 CD 患者和 47 例 UC 患者）和 520 例对照。IBD 患者（9.6%，25/260）和新诊断 IBD 患者（12.1%，8/66）、CD 患者（8.9%，19/213）包括新诊断 CD 患者（10.6%，5/47）和 UC 患者（12.8%，6/47）的 H. pylori 感染率明显低于对照（29.8%，155/520）（p=2.79610-10，0.007，5.72310-9，0.016，0.014），但新诊断 UC 患者与对照之间，以及不同疾病类型、疾病活动度和治疗史的 IBD 患者之间无统计学差异。
H. pylori 感染与 IBD 呈负相关，尤其是 CD。
