Institute for Physical Chemistry, University of Münster, Corrensstrasse 30, D-48149Münster, Germany.
Biol Chem. 2021 Mar 15;402(5):645-651. doi: 10.1515/hsz-2020-0367. Print 2021 Apr 27.
DEAD-box helicases participate in nearly all steps of an RNA's life. In recent years, increasing evidence has shown that several family members are multitasking enzymes. They are often involved in different processes, which may be typical for RNA helicases, such as RNA export and translation, or atypical, e.g., acting as nucleic acid sensors that activate downstream innate immune signaling. This review focuses on the DEAD-box protein DDX41 and summarizes our current understanding of its roles as an innate immunity sensor in the cytosol and in pre-mRNA splicing in the nucleus and discusses DDX41's involvement in disease.
DEAD-box 解旋酶参与 RNA 生命周期的几乎所有步骤。近年来，越来越多的证据表明，有几个家族成员是多功能酶。它们通常参与不同的过程，这对于 RNA 解旋酶来说可能是典型的，例如 RNA 输出和翻译，或者是非典型的，例如作为激活下游先天免疫信号的核酸传感器。这篇综述重点介绍了 DEAD-box 蛋白 DDX41，并总结了我们目前对其作为细胞质中先天免疫传感器和核内前体 mRNA 剪接中的作用的认识，并讨论了 DDX41 在疾病中的作用。
