Division of PET Imaging, Shiga Medical Center Research Institute, 5-4-30, Moriyama-cho, Moriyama, Shiga, 524-8524, Japan.
Division of PET Imaging, Shiga Medical Center Research Institute, 5-4-30, Moriyama-cho, Moriyama, Shiga, 524-8524, Japan; Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), 4-9-1, Anagawa, Inage-ku, Chiba, 263-0024, Japan.
Alcohol. 2021 Sep;95:15-23. doi: 10.1016/j.alcohol.2021.03.003. Epub 2021 Mar 10.
Alcohol flushing reaction (AFR) is known as one of the risks for esophageal squamous cell cancer, and scientists have been elucidating this issue. However, little attention has been given to relevant imaging features. This study aims to investigate whether physiological F-fluorodeoxyglucose (FDG) uptake patterns in vertebrae are associated with drinking habits or AFR. Japanese male patients who underwent FDG positron emission computed tomography for evaluation of their known or suspected malignancies or inflammatory diseases were asked about their drinking habits and AFR. Altogether, 192 patients, 139 every-day drinkers and 53 non-drinkers were evaluated. Comparing the FDG uptake between that in the thoracic region and that in the lumbar region, vertebral uptake was visually classified into four patterns: Ld, dominant in lumbar region; TL, almost equal in both regions; BL, slightly higher in thoracic region (borderline pattern); Td, dominant in thoracic region. The uptake patterns were evaluated according to drinking habit (every-day drinker or non-drinker), AFR (flusher or non-flusher), and the combination of these two factors (habit/reaction: every-day drinker/flusher, every-day drinker/non-flusher, non-drinker/flusher, or non-drinker/non-flusher). There were 95 flushers (51 every-day drinkers and 44 non-drinkers) and 97 non-flushers (88 every-day drinkers and 9 non-drinkers). Ld, TL, BL, and Td patterns were observed in 0, 109 (56.8%), 31 (16.1%), and 52 (27.1%) patients, respectively. Td and BL patterns were more frequently observed in every-day drinkers compared with non-drinkers (p = 0.0467). Though the uptake patterns did not differ between flushers and non-flushers (p = 0.116), the Td pattern was more frequently observed in every-day drinkers/flushers (51%) compared with every-day drinkers/non-flushers (20.5%), non-drinkers/flushers (13.6%), and non-drinkers/non-flushers (22.2%) (p = 0.0014). The Td pattern was observed in patients with various diseases, with higher frequency in esophageal cancer, head and neck cancer, and lung cancer compared with other diseases. In conclusion, drinking habits and AFR were related to the vertebral uptake pattern with decreased uptake in the lumbar region in Japanese male patients.
酒精潮红反应（AFR）被认为是食管癌的风险因素之一，科学家们一直在阐明这个问题。然而，很少有人关注相关的影像学特征。本研究旨在探讨脊椎生理 F-氟脱氧葡萄糖（FDG）摄取模式是否与饮酒习惯或 AFR 有关。日本男性患者因已知或疑似恶性肿瘤或炎症性疾病接受 FDG 正电子发射计算机断层扫描（PET/CT）检查，询问他们的饮酒习惯和 AFR。共评估了 192 名患者，其中 139 名为每日饮酒者，53 名为非饮酒者。比较胸区和腰区的 FDG 摄取，根据脊椎摄取的视觉分类，将脊椎摄取分为四种模式：Ld，腰椎区优势；TL，两者区域几乎相等；BL，胸区略高（边界模式）；Td，胸椎区优势。根据饮酒习惯（每日饮酒者或非饮酒者）、AFR（潮红者或非潮红者）以及这两个因素的组合（习惯/反应：每日饮酒者/潮红者、每日饮酒者/非潮红者、非饮酒者/潮红者或非饮酒者/非潮红者）对摄取模式进行评估。潮红者 95 例（每日饮酒者 51 例，非饮酒者 44 例），非潮红者 97 例（每日饮酒者 88 例，非饮酒者 9 例）。分别观察到 0、109（56.8%）、31（16.1%）和 52（27.1%）例患者出现 Ld、TL、BL 和 Td 模式。与非饮酒者相比，每日饮酒者更常出现 Td 和 BL 模式（p=0.0467）。尽管潮红者和非潮红者的摄取模式无差异（p=0.116），但每日饮酒者/潮红者（51%）较每日饮酒者/非潮红者（20.5%）、非饮酒者/潮红者（13.6%）和非饮酒者/非潮红者（22.2%）更常出现 Td 模式（p=0.0014）。在患有各种疾病的患者中观察到 Td 模式，与其他疾病相比，食管癌、头颈部癌症和肺癌患者的 Td 模式出现频率更高。总之，日本男性患者的饮酒习惯和 AFR 与脊椎摄取模式有关，表现为腰椎区摄取减少。
