Mehta Asmita A, Haridas Nithya, Belgundi Preeti, Jose Wesley M
Department of Respiratory Medicine, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeethem, Ponekara, Kochi-682041, Kerala, India.
Department of Pulmonary Medicine, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeethem, Ponekara, Kochi-682041, Kerala, India.
Diabetes Metab Syndr. 2021 Mar-Apr;15(2):535-541. doi: 10.1016/j.dsx.2021.02.020. Epub 2021 Feb 20.
Corona virus disease 2019 (COVID-19) has been an extremely difficult pandemic to contain and it has affected more than 148 countries worldwide. The main aim of this systematic review is to provide a comprehensive summary of clinical and laboratory parameters that are associated with and indicative of increased severity among COVID-19 patients.
All the available data from high-quality research articles relevant to the epidemiology, demographics, trends in hospitalization and outcomes, clinical signs and symptoms, diagnostic methods and treatment methods of COVID-19 were retrieved and evaluated for inclusion.
As per our review, the mean age of patients in the severe group was 59.3 years compared to 46.5 years in non severe group. COVID-19 was more severe among men than women. Clinical presentation was variable among different studies. and dyspnea was the factor indicating severe disease. Laboratory parameters associated with increased severity were lymphopenia <0.8 × 10/L, thrombocytopenia 100 × 10/L, leucocytosis TC > 11 × 10/L, procalcitonin >0.5 ng/mL, d dimer >2 mcg/mL, aspartate transaminase elevation >150U/L, LDH >250U/L.
This systematic review suggests that COVID-19 is a disease with varied clinical presentation and laboratory parameters. The commonest clinical symptoms were fever, cough and dyspnea. The laboratory parameters associated with severe disease were lymphopenia, elevated LDH, D dimer and Procalcitonin.
2019年冠状病毒病（COVID-19）是一种极难控制的大流行病，已影响全球148多个国家。本系统评价的主要目的是全面总结与COVID-19患者病情严重程度增加相关并可指示病情严重程度增加的临床和实验室参数。
检索并评估了与COVID-19的流行病学、人口统计学、住院趋势及转归、临床体征和症状、诊断方法及治疗方法相关的高质量研究文章中的所有可用数据，以确定是否纳入。
根据我们的评价，重症组患者的平均年龄为59.3岁，非重症组为46.5岁。COVID-19在男性中比在女性中更严重。不同研究中的临床表现各不相同，呼吸困难是指示疾病严重的因素。与病情严重程度增加相关的实验室参数包括淋巴细胞减少<0.8×10⁹/L、血小板减少<100×10⁹/L、白细胞增多症（总细胞数>11×10⁹/L）、降钙素原>0.5 ng/mL、D-二聚体>2 mcg/mL、天冬氨酸转氨酶升高>150 U/L、乳酸脱氢酶>250 U/L。
本系统评价表明，COVID-19是一种临床表现和实验室参数各异的疾病。最常见的临床症状是发热、咳嗽和呼吸困难。与重症疾病相关的实验室参数是淋巴细胞减少、乳酸脱氢酶升高、D-二聚体和降钙素原升高。
