Department of Brain and Cognitive Science, Seoul National University College of Natural Sciences, Seoul, South Korea.
Department of Neuropsychiatry, Seoul National University Bundang Hospital, Gyeonggido, South Korea.
Neuroimage Clin. 2021;30:102607. doi: 10.1016/j.nicl.2021.102607. Epub 2021 Mar 4.
Although two white matter hyperintensity (WMH) probability maps of healthy older adults already exist, they have several limitations in representing the distribution of WMH in healthy older adults, especially Asian older adults. We constructed and validated a WMH probability map (WPM) of healthy older Koreans and examined the age-associated differences of WMH.
We constructed WPM using development dataset that consisted of high-resolution 3D fluid-attenuated inversion recovery images of 5 age groups (60-64 years, 65-69 years, 70-74 years, 75-79 years, and 80+ years). Each age group included 30 age-matched men and women each. We tested the validity of the WPM by comparing WMH ages estimated by the WPM and the chronological ages of 30 healthy controls, 30 hypertension patients, and 30 S patients.
Older age groups showed a higher volume of WMH in both hemispheres (p < 0.001). About 90% of the WMH were periventricular in all age groups. With advancing age, the peak of the distance histogram from the ventricular wall of the periventricular WMH shifted away from the ventricular wall, while that of deep WMH shifted toward the ventricular wall. The estimated WMH ages were comparable to the chronological ages in the healthy controls, while being higher than the chronological ages in hypertension and stroke patients.
This WPM may serve as a standard atlas in research on WMH of older adults, especially Asians.
尽管已有两种针对健康老年人的脑白质高信号（WMH）概率图谱，但它们在代表健康老年人，尤其是亚洲老年人的 WMH 分布方面存在一些局限性。我们构建并验证了一种针对健康韩国老年人的 WMH 概率图谱（WPM），并研究了其与年龄相关的差异。
我们使用包含 5 个年龄组（60-64 岁、65-69 岁、70-74 岁、75-79 岁和 80 岁以上）的高分辨率 3D 液体衰减反转恢复图像的开发数据集构建了 WPM。每个年龄组包含 30 名年龄匹配的男性和女性。我们通过比较 WPM 估计的 WMH 年龄与 30 名健康对照者、30 名高血压患者和 30 名 S 患者的实际年龄来验证 WPM 的有效性。
年龄较大的组在两个半球的 WMH 体积均较高（p<0.001）。所有年龄组的 WMH 约有 90%为脑室周围型。随着年龄的增长，脑室周围型 WMH 距脑室壁距离直方图的峰值逐渐远离脑室壁，而深部 WMH 的峰值逐渐靠近脑室壁。估计的 WMH 年龄与健康对照组的实际年龄相当，但高于高血压和中风患者的实际年龄。
该 WPM 可作为研究老年人，尤其是亚洲老年人 WMH 的标准图谱。
