Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China; Hunan Key Laboratory of Medical Epigenetics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
Department of Dermatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China.
Environ Pollut. 2021 Jun 1;278:116850. doi: 10.1016/j.envpol.2021.116850. Epub 2021 Mar 2.
Particulate matter with an aerodynamic equivalent diameter of 2.5 μm or less in ambient air (PM2.5) has become a global public and environmental problem, and the control of the PM2.5 concentration in air is an urgent problem. PM2.5 can easily penetrate the skin, activating the inflammatory response in skin, unbalancing the skin barrier function, and inducing skin aging. Hyperpigmentation is the main manifestation of skin aging and has a considerable impact on quality of life worldwide. To date, no research on the influence of PM2.5 on hyperpigmentation has been conducted. Here, we illustrate that PM2.5 can induce melanogenesis in vivo and in vitro by regulating TYR, TYRP1, TYRP2, and MITF expression via AhR/MAPK signaling activation. Furthermore, PM2.5 increased α-MSH paracrine levels, which in turn promote hyperpigmentation. Our results provide a deeper understanding of how PM2.5 disrupts skin homeostasis and function. Treatment with AhR antagonists may be a potential therapeutic strategy for hyperpigmentation induced by PM2.5.
空气中的空气动力学等效直径为 2.5μm 或更小的颗粒物（PM2.5）已成为全球公共和环境问题，控制空气中的 PM2.5 浓度是一个紧迫的问题。PM2.5 很容易穿透皮肤，激活皮肤中的炎症反应，破坏皮肤屏障功能，并诱导皮肤老化。皮肤色素沉着过度是皮肤老化的主要表现，对全球的生活质量有相当大的影响。迄今为止，还没有研究 PM2.5 对色素沉着过度的影响。在这里，我们通过 AhR/MAPK 信号通路的激活来表明 PM2.5 可以通过调节 TYR、TYRP1、TYRP2 和 MITF 的表达来诱导体内和体外的黑色素生成。此外，PM2.5 增加了 α-MSH 旁分泌水平，进而促进了色素沉着过度。我们的结果提供了对 PM2.5 如何破坏皮肤内稳态和功能的更深入了解。使用 AhR 拮抗剂治疗可能是 PM2.5 诱导的色素沉着过度的一种潜在治疗策略。
