Department of Dermatology, Peking University People's Hospital, Beijing 100044, China.
Department of Dermatology, Graduate School of Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan; Research and Clinical Center for Yusho and Dioxin, Kyushu University Hospital, Fukuoka 812-8582, Japan.
Environ Int. 2019 Nov;132:105063. doi: 10.1016/j.envint.2019.105063. Epub 2019 Aug 6.
Ambient particulate matter 2.5 (PM) is one of the main components of air pollutants, which can absorb many polycyclic aromatic hydrocarbons and metals. The effect of PM on human skin and its biological significance in skin homeostasis remain incompletely understood. Previous studies demonstrated that PM can activate aryl hydrocarbon receptor (AhR), generate reactive oxygen species, and induce skin inflammation. These processes may be involved in melanocyte homeostasis and melanogenesis. We hypothesize that AhR signaling may be responsible for PM-related hyperpigmentation.
环境细颗粒物 2.5（PM）是空气污染物的主要成分之一，可吸附多种多环芳烃和金属。PM 对人类皮肤的影响及其在皮肤稳态中的生物学意义尚不完全清楚。先前的研究表明，PM 可激活芳香烃受体（AhR），产生活性氧物质，并引发皮肤炎症。这些过程可能与黑素细胞稳态和黑色素生成有关。我们假设 AhR 信号可能与 PM 相关的色素沉着过度有关。
