乙酰辅酶A与代谢物通量调节白色脂肪组织扩张。
Acetyl-CoA and Metabolite Fluxes Regulate White Adipose Tissue Expansion.
作者信息
Felix Jessica B, Cox Aaron R, Hartig Sean M
机构信息
Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, TX, USA; Department of Medicine, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, TX, USA; Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
出版信息
Trends Endocrinol Metab. 2021 May;32(5):320-332. doi: 10.1016/j.tem.2021.02.008. Epub 2021 Mar 9.
Abstract
White adipose tissue (WAT) depends on coordinated regulation of transcriptional and metabolic pathways to respond to whole-body energy demands. We highlight metabolites that contribute to biosynthetic reactions for WAT expansion. Recent studies have precisely defined how byproducts of carbohydrate and lipid metabolism affect physiological and endocrine functions in adipocytes. We emphasize the critical emerging roles of short-chain fatty acids (SCFAs) and tricarboxylic acid (TCA) cycle metabolites that connect lipogenesis to WAT energy balance and endocrine functions. These insights address how adipocytes use small molecules generated from central carbon metabolism to measure responses to nutritional stress.
摘要
白色脂肪组织（WAT）依赖于转录和代谢途径的协调调节来响应全身能量需求。我们着重介绍了有助于白色脂肪组织扩张的生物合成反应的代谢物。最近的研究已经精确地确定了碳水化合物和脂质代谢的副产物如何影响脂肪细胞中的生理和内分泌功能。我们强调短链脂肪酸（SCFAs）和三羧酸（TCA）循环代谢物的关键新兴作用，它们将脂肪生成与白色脂肪组织的能量平衡和内分泌功能联系起来。这些见解阐述了脂肪细胞如何利用中心碳代谢产生的小分子来衡量对营养应激的反应。
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