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[双侧豆状核病变引起的强迫行为。一例新病例]

[Obsessive-compulsive behavior caused by bilateral lesions of the lenticular nuclei. A new case].

作者信息

Laplane D, Boulliat J, Baron J C, Pillon B, Baulac M

机构信息

Service de Neurologie, CHU Pitié-Salpêtrière, Paris.

出版信息

Encephale. 1988 Jan-Feb;14(1):27-32.

PMID:3371250
Abstract

Another case of obsessive behaviour as the consequence of lentiform nuclei lesions is reported. All the aspects of an obsessive neurosis were present: irresistible compulsiveness, acute anxiety in case of non accomplishment, magic-like clues. The symptoms appeared after a carbon monoxide poisoning, in a 31-years-old woman who had previously a pathological personality, of the psychopathic type, but without obsessive features. The onset of compulsions was paralleled by frontal-like psychological changes, but there was no reduction of intellectual or mnesic functions. A previous depressive state continued after the poisoning, so that the patient did not show an empty mind as did the other patients; the loss of "self-psychic activation" was only partial. All these case-reports emphasize the fact that the neuropsychological testing must not be limited to the behaviour and must investigate the "mental content" as well. They also lead us to emphasize similitudes between psychic disorders related to lenticular lesions and those related to frontal lobe lesions, including obsessive-like activities. Such case-reports provide a model in which some components of the obsessive neurosis, hebephrenia and depression are the consequence of an identified brain damage. It can be suggested that the neural circuits involving frontal lobes and parts of the neostriatum and of the pallidum are implicated in the mechanisms of these three types of psychoses.

摘要

本文报告了另一例因豆状核病变导致强迫行为的病例。该病例呈现出强迫性神经症的所有特征:无法抗拒的强迫性、未完成任务时的急性焦虑以及类似魔法的线索。症状出现在一名31岁女性一氧化碳中毒之后,该女性之前具有病态人格,属于精神病类型,但无强迫特征。强迫症状出现的同时伴有类似额叶病变的心理变化,但智力和记忆功能并未减退。中毒后之前的抑郁状态持续存在,因此该患者不像其他患者那样思维空白,“自我心理激活”的丧失只是部分性的。所有这些病例报告都强调了一个事实,即神经心理学测试不能仅限于行为,还必须调查“心理内容”。它们还促使我们强调与豆状核病变相关的精神障碍与与额叶病变相关的精神障碍之间的相似性,包括类似强迫的活动。此类病例报告提供了一个模型,其中强迫性神经症、青春期痴呆和抑郁症的某些成分是特定脑损伤的结果。可以推测,涉及额叶以及新纹状体和苍白球部分的神经回路与这三种精神病的发病机制有关。

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