Suttie J M, Fennessy P F, Gluckman P D, Corson I D
Invermay Agricultural Centre, Mosgiel, New Zealand.
Endocrinology. 1988 Jun;122(6):3005-7. doi: 10.1210/endo-122-6-3005.
We have previously shown that plasma IGF 1 concentration is positively correlated with the rate of antler growth and have proposed that IGF 1 is stimulatory for antler growth in the red deer stag. Therefore to partly resolve the question of whether the IGF 1 was of circulating or local origin in relation to its effect on antler growth, we surgically prevented stags from growing antlers. We recorded significantly elevated plasma levels of IGF 1 in the non-antlered stags compared with normal antlered stags during the antler growth periods. This result is consistent with a hypothesis that the antler is a target organ for IGF 1 and that prevention of antler growth removed a population of IGF 1 receptors. IGF 1 is already known to stimulate body growth but this work points strongly to the possibility that plasma IGF 1 may stimulate individual organ growth in an endocrine manner.
我们之前已经表明，血浆中胰岛素样生长因子1（IGF 1）的浓度与鹿茸生长速率呈正相关，并提出IGF 1对马鹿雄鹿的鹿茸生长具有刺激作用。因此，为了部分解决IGF 1对鹿茸生长的影响是源于循环还是局部这一问题，我们通过手术阻止雄鹿生长鹿茸。我们记录到，在鹿茸生长期间，与正常长茸雄鹿相比，不长茸雄鹿的血浆IGF 1水平显著升高。这一结果与以下假设一致：鹿茸是IGF 1的靶器官，阻止鹿茸生长会去除一部分IGF 1受体。已知IGF 1可刺激身体生长，但这项研究有力地表明，血浆IGF 1可能以内分泌方式刺激单个器官生长。
