Suttie J M, Gluckman P D, Butler J H, Fennessy P F, Corson I D, Laas F J
Endocrinology. 1985 Feb;116(2):846-8. doi: 10.1210/endo-116-2-846.
We have investigated the possibility that IGF-1 may play a role in the regulation of antler development. Plasma IGF-1 concentrations were measured throughout the first period of development of the pedicle and first antler of red deer (Cervus elaphus) to determine whether a relationship existed between growth of antler cartilage (velvet antler) and IGF-1. We report that plasma levels of IGF-1 are significantly elevated during the velvet antler growing phase relative to the other phases of pedicle and first antler development and a strong positive correlation exists between antler growth rate and circulating concentrations of IGF-1. As IGF-1 has been demonstrated to influence cartilage growth, we suggest that IGF-1 is a candidate as an antler stimulating hormone.
我们研究了胰岛素样生长因子-1（IGF-1）可能在鹿茸发育调节中发挥作用的可能性。在马鹿（Cervus elaphus）鹿茸基部和初角发育的第一个阶段，全程测量血浆IGF-1浓度，以确定鹿茸软骨（鹿茸）生长与IGF-1之间是否存在关联。我们报告称，与鹿茸基部和初角发育的其他阶段相比，鹿茸生长阶段血浆IGF-1水平显著升高，并且鹿茸生长速率与循环中的IGF-1浓度之间存在强正相关。由于IGF-1已被证明会影响软骨生长，我们认为IGF-1是一种促鹿茸生长激素的候选物质。
