School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.
Centenary Institute, The University of Sydney, Sydney, NSW, Australia.
J Mol Med (Berl). 2021 Jun;99(6):755-769. doi: 10.1007/s00109-021-02060-8. Epub 2021 Mar 12.
microRNA are small non-coding RNA molecules which inhibit gene expression by binding mRNA, preventing its translation. As important regulators of gene expression, there is increasing interest in microRNAs as potential diagnostic biomarkers and therapeutic targets. Studies investigating the role of one of the miRNA-miR-652-3p-detail diverse roles for this miRNA in normal cell homoeostasis and disease states, including cancers, cardiovascular disease, mental health, and central nervous system diseases. Here, we review recent literature surrounding miR-652-3p, discussing its known target genes and their relevance to disease progression. These studies demonstrate that miR-652-3p targets LLGL1 and ZEB1 to modulate cell polarity mechanisms, with impacts on cancer metastasis and asymmetric cell division. Inhibition of the NOTCH ligand JAG1 by miR-652-3p can have diverse effects on angiogenesis and immune cell regulation. Investigation of miR-652-3p and other dysregulated miRNAs identified a number of pathways potentially regulated by miR-652-3p. This review demonstrates that miR-652-3p has great promise as a diagnostic or therapeutic target due to its activity across multiple cellular systems.
miRNA 是一类小的非编码 RNA 分子，通过与 mRNA 结合来抑制基因表达，从而阻止其翻译。作为基因表达的重要调控因子，miRNA 作为潜在的诊断生物标志物和治疗靶点引起了越来越多的关注。研究表明，miR-652-3p 在正常细胞稳态和疾病状态（包括癌症、心血管疾病、心理健康和中枢神经系统疾病）中发挥着多样化的作用。在这里，我们回顾了最近关于 miR-652-3p 的文献，讨论了其已知的靶基因及其与疾病进展的相关性。这些研究表明，miR-652-3p 靶向 LLGL1 和 ZEB1 来调节细胞极性机制，对癌症转移和不对称细胞分裂有影响。miR-652-3p 对 NOTCH 配体 JAG1 的抑制作用对血管生成和免疫细胞调节有不同的影响。对 miR-652-3p 和其他失调 miRNA 的研究确定了一些可能受 miR-652-3p 调控的途径。本综述表明，由于 miR-652-3p 在多个细胞系统中的活性，它具有作为诊断或治疗靶点的巨大潜力。
