Taslakian Editt N, Wi Chung-Il, Seol Hee Yun, Boyce Thomas G, Johnson Jonathan N, Ryu Euijung, King Katherine S, Juhn Young J, Choi Bong Seok
Division of Plastic Surgery, Department of Surgery, University of Washington Medical Center, Seattle, WA, USA.
Precision Population Science Lab, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Pediatr Cardiol. 2021 Jun;42(5):1033-1040. doi: 10.1007/s00246-021-02577-2. Epub 2021 Mar 12.
To assess the longitudinal incidence of Kawasaki disease (KD) within the well-defined predominantly White population of Olmsted County, MN. This retrospective cohort study used a population-based medical record linkage system and manual chart reviews to identify children with KD in Olmsted County, MN between January 1, 1979-December 31, 2016. Age- and gender-adjusted incidence rates were calculated using the 2010 U.S. White population. 124 children with KD were confirmed during the study period (median age 3.5, 61% male, 85% White, 9% Asian). The overall age- and gender-adjusted incidence rates for all ages and < 5 years old were 9.8 and 21.4 per 100,000 person-years, respectively. There was an overall increase in incidence up to 1994 followed by plateau, except among children between the ages of 1-5 years. There was also an overall increase in incidence among females compared to males. 24% of children had cardiac complications. While the overall incidence of KD in Olmsted County appears to be stable since 1994, the incidence of KD in subgroups of children 1-5 years old and females seems to have increased. Given the rising trends and one-quarter of children developing cardiac complications, further studies identifying factors driving these trends are warranted.
为评估明尼苏达州奥尔姆斯特德县以白人为主的明确人群中川崎病（KD）的纵向发病率。这项回顾性队列研究使用了基于人群的医疗记录链接系统和人工病历审查，以确定1979年1月1日至2016年12月31日期间明尼苏达州奥尔姆斯特德县患有KD的儿童。年龄和性别调整后的发病率是使用2010年美国白人人口数据计算得出的。在研究期间确诊了124例KD患儿（中位年龄3.5岁，61%为男性，85%为白人，9%为亚洲人）。所有年龄段和＜5岁儿童的总体年龄和性别调整发病率分别为每10万人年9.8例和21.4例。直到1994年发病率总体呈上升趋势，之后趋于平稳，但1 - 5岁儿童除外。女性的发病率总体也高于男性。24%的儿童出现了心脏并发症。虽然自1994年以来奥尔姆斯特德县KD的总体发病率似乎稳定，但1 - 5岁儿童亚组和女性的KD发病率似乎有所上升。鉴于发病率呈上升趋势且四分之一的儿童出现心脏并发症，有必要进一步开展研究以确定导致这些趋势的因素。
