富含鸟嘌呤序列结合因子 1（GRSF1）的表达调控、蛋白质化学和功能生物学。

Expression Regulation, Protein Chemistry and Functional Biology of the Guanine-Rich Sequence Binding Factor 1 (GRSF1).

机构信息

Institute of Biochemistry, Charité - University Medicine Berlin, Corporate Member of Free University Berlin, Humboldt University Berlin and Berlin Institute of Health, Charitéplatz 1, D-10117 Berlin, Germany; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

出版信息

J Mol Biol. 2021 Jun 25;433(13):166922. doi: 10.1016/j.jmb.2021.166922. Epub 2021 Mar 10.

DOI:10.1016/j.jmb.2021.166922

PMID:33713675

Abstract

In eukaryotic cells RNA-binding proteins have been implicated in virtually all post-transcriptional mechanisms of gene expression regulation. Based on the structural features of their RNA binding domains these proteins have been divided into several subfamilies. The presence of at least two RNA recognition motifs defines the group of heterogenous nuclear ribonucleoproteins H/F and one of its members is the guanine-rich sequence binding factor 1 (GRSF1). GRSF1 was first described 25 years ago and is widely distributed in eukaryotic cells. It is present in the nucleus, the cytoplasm and in mitochondria and has been implicated in a variety of physiological processes (embryogenesis, erythropoiesis, redox homeostasis, RNA metabolism) but also in the pathogenesis of various diseases. This review summarizes our current understanding on GRSF1 biology, critically discusses the literature reports and gives an outlook of future developments in the field.

摘要

在真核细胞中，RNA 结合蛋白已被牵涉到几乎所有的基因表达调控的转录后机制中。根据其 RNA 结合结构域的结构特征，这些蛋白已被分为几个亚家族。至少有两个 RNA 识别基序的存在定义了异质核核糖核蛋白 H/F 组，其成员之一是富含鸟嘌呤的序列结合因子 1 (GRSF1)。GRSF1 最初是在 25 年前描述的，在真核细胞中广泛分布。它存在于细胞核、细胞质和线粒体中，并被牵涉到各种生理过程（胚胎发生、红细胞生成、氧化还原稳态、RNA 代谢），也与各种疾病的发病机制有关。这篇综述总结了我们目前对 GRSF1 生物学的理解，批判性地讨论了文献报道，并展望了该领域的未来发展。