Department of Wound Stoma Care Clinic, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, Guangdong, China.
Department of Wound Stoma Care Clinic, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, Guangdong, China.
Diabetes Res Clin Pract. 2021 Apr;174:108743. doi: 10.1016/j.diabres.2021.108743. Epub 2021 Mar 10.
To investigate the therapeutic effect of continuous diffusion of oxygen (CDO) combined with traditional moist wound dressing (MWD) on the diabetic foot ulcers (DFUs) inpatients.
The inpatients from May 2016 to April 2018 were enrolled and randomly divided into MWD, CDO and combination treatment groups (n = 40 each group). The moist dressing was used in the MWD group while a micro-oxygen supply device was used in the CDO group. The combination treatment group was given both MWD and CDO. All patients were treated for 8 weeks. The wound healing, amputation rate, and inflammatory control were evaluated.
Compared with MWD and CDO groups, the combination group showed a higher wound healing rate (P < 0.05), lower white blood cell count (P < 0.05) and lower high-sensitivity C-reactive protein level (P < 0.05). During 1-year follow-up, the amputation rate was 0% in combination group, which was significantly lower than that in other two groups (P < 0.05).
The combination of MWD and CDO was effective in promoting healing and preventing infection of DFUs, which holds a potential to be a new strategy for the treatment of this critical clinical condition.
研究持续氧气扩散（CDO）联合传统湿性伤口敷料（MWD）对糖尿病足溃疡（DFU）住院患者的治疗效果。
选取 2016 年 5 月至 2018 年 4 月住院的患者，随机分为 MWD 组、CDO 组和联合治疗组（每组 40 例）。MWD 组采用湿性敷料，CDO 组采用微氧供应装置。联合治疗组同时给予 MWD 和 CDO。所有患者均治疗 8 周。评估伤口愈合、截肢率和炎症控制情况。
与 MWD 组和 CDO 组相比，联合治疗组的伤口愈合率更高（P<0.05），白细胞计数更低（P<0.05），高敏 C 反应蛋白水平更低（P<0.05）。在 1 年随访期间，联合治疗组的截肢率为 0%，明显低于其他两组（P<0.05）。
MWD 和 CDO 的联合应用在促进 DFU 愈合和预防感染方面有效，可能成为治疗这种危急临床情况的新策略。
