Department of Plastic Reconstructive and Aesthetic Surgery, Faculty of Medicine, Airlangga University, Surabaya, Indonesia.
Plastic Reconstructive and Aesthetic Surgery Unit, Airlangga University Hospital, Surabaya, Indonesia.
Int Wound J. 2024 Jul;21(7):e14960. doi: 10.1111/iwj.14960.
In preclinical studies, topical oxygen treatment (TOT) was shown to enhance wound healing by applying supplemental oxygen topically to the surface of a moist wound at normobaric conditions. The objective of this systematic review and meta-analysis is to provide a thorough evaluation of published RCTs and observational studies that compare supplemental TOT with standard wound care. A total of 1077 studies were obtained from a variety of databases, including PubMed, ScienceDirect, Web of Science, ProQuest, Scopus, ClinicalTrials.gov, EU Clinical Trial Registers, and Preprints.org. The Jadad scale was employed to assess the reliability of RCT studies, while the Newcastle-Ottawa Scale (NOS) was employed to assess the quality of observational studies. Seven RCT studies (n = 692) and two controlled observational studies (n = 111) were analysed. The rate of healed wounds was 25.8% in the control group and 43.25% in the adjuvant TOT group, which shows the use of TOT significantly increased the number of healed wounds (RR = 1.77; 95% CI 1.18-2.64; p = 0.005). A significant decrease in the percentage of wound area was found in the TOT group in RCT studies (mean difference = 15.64; 95% CI 5.22-26.06; p = 0.003). In observational studies, the rate of healed wounds was 37.5% in the standard care group and 80.95% in the adjuvant TOT group, which shows a significant increase in the number of healed wounds in the adjuvant TOT group (RR = 2.15; 95% CI 1.46-3.15; p < 0.00001). Topical oxygen therapy is considered a great adjuvant therapy for chronic wound healing, particularly wounds with vascular compromise such as diabetic ulcers and pressure ulcers. Further studies on this topic are still needed as there are a lot of potential uses for this technology in various types of wounds.
在临床前研究中，通过在常压条件下将补充氧气局部应用于湿润伤口的表面，局部氧治疗（TOT）被证明可以增强伤口愈合。本系统评价和荟萃分析的目的是全面评估已发表的 RCT 和观察性研究，这些研究比较了补充 TOT 与标准伤口护理。从各种数据库（包括 PubMed、ScienceDirect、Web of Science、ProQuest、Scopus、ClinicalTrials.gov、EU Clinical Trial Registers 和 Preprints.org）共获得了 1077 项研究。使用 Jadad 量表评估 RCT 研究的可靠性，而使用纽卡斯尔-渥太华量表（NOS）评估观察性研究的质量。分析了 7 项 RCT 研究（n=692）和 2 项对照观察性研究（n=111）。对照组的愈合伤口率为 25.8%，辅助 TOT 组为 43.25%，这表明使用 TOT 显著增加了愈合伤口的数量（RR=1.77；95%CI 1.18-2.64；p=0.005）。RCT 研究中 TOT 组的伤口面积百分比显著降低（平均差异=15.64；95%CI 5.22-26.06；p=0.003）。在观察性研究中，标准护理组的愈合伤口率为 37.5%，辅助 TOT 组为 80.95%，这表明辅助 TOT 组的愈合伤口数量显著增加（RR=2.15；95%CI 1.46-3.15；p<0.00001）。局部氧疗法被认为是慢性伤口愈合的一种很好的辅助治疗方法，特别是对于血管受损的伤口，如糖尿病溃疡和压疮。由于这项技术在各种类型的伤口中有很多潜在的用途，因此仍需要对此进行更多的研究。
