新型噻唑并[4,5-d]嘧啶与（1H-1,2,4）三唑杂合化合物的合成及抗真菌活性。
Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole.
机构信息
G. A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences, 1 Akademicheskaya Street, 153045 Ivanovo, Russian Federation.
G. A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences, 1 Akademicheskaya Street, 153045 Ivanovo, Russian Federation.
出版信息
Bioorg Med Chem Lett. 2021 May 15;40:127944. doi: 10.1016/j.bmcl.2021.127944. Epub 2021 Mar 11.
Synthesis and antifungal activity of hybrids of thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazoles are presented. The solubility and lipophilicity of compounds was assessed and it was discovered that compounds with piperazine linker exhibited significant antifungal activity against filamentous and yeast fungi.
本文介绍了噻唑并[4,5-d]嘧啶与（1H-1,2,4）三唑杂合体的合成及抗真菌活性。评估了化合物的溶解度和脂溶性，发现带有哌嗪连接基的化合物对丝状真菌和酵母真菌具有显著的抗真菌活性。
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