• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

新型噻唑并[4,5-d]嘧啶与（1H-1,2,4）三唑杂合化合物的合成及抗真菌活性。

Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole.

机构信息

G. A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences, 1 Akademicheskaya Street, 153045 Ivanovo, Russian Federation.

G. A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences, 1 Akademicheskaya Street, 153045 Ivanovo, Russian Federation.

出版信息

Bioorg Med Chem Lett. 2021 May 15;40:127944. doi: 10.1016/j.bmcl.2021.127944. Epub 2021 Mar 11.

DOI:10.1016/j.bmcl.2021.127944
PMID:33713781
Abstract

Synthesis and antifungal activity of hybrids of thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazoles are presented. The solubility and lipophilicity of compounds was assessed and it was discovered that compounds with piperazine linker exhibited significant antifungal activity against filamentous and yeast fungi.

摘要

本文介绍了噻唑并[4,5-d]嘧啶与（1H-1,2,4）三唑杂合体的合成及抗真菌活性。评估了化合物的溶解度和脂溶性，发现带有哌嗪连接基的化合物对丝状真菌和酵母真菌具有显著的抗真菌活性。

相似文献

1
Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole.新型噻唑并[4,5-d]嘧啶与（1H-1,2,4）三唑杂合化合物的合成及抗真菌活性。
Bioorg Med Chem Lett. 2021 May 15;40:127944. doi: 10.1016/j.bmcl.2021.127944. Epub 2021 Mar 11.
2
Synthesis and antimicrobial evaluation of some new thiazolo[4,5-d] pyrimidines.一些新型噻唑并[4,5-d]嘧啶的合成与抗菌活性评价
Arzneimittelforschung. 2001 Oct;51(10):839-42. doi: 10.1055/s-0031-1300123.
3
Synthesis and biological activity of new heterocyclic structures: [1,3]thiazino[2,3-i]purine, thiazolo[3,2-c] [1,2,3]triazolo[4,5-e]pyrimidine and [1,2,3]triazolo [4', 5': 4,5] pyrimido[6,1-b][1,3]thiazine.新型杂环结构的合成与生物活性：[1,3]噻嗪并[2,3-i]嘌呤、噻唑并[3,2-c][1,2,3]三唑并[4,5-e]嘧啶和[1,2,3]三唑并[4',5':4,5]嘧啶并[6,1-b][1,3]噻嗪
Farmaco. 1992 Oct;47(10):1315-22.
4
Synthesis and antifungal activity of novel thiazole-containing triazole antifungals.新型含噻唑三唑类抗真菌剂的合成及其抗真菌活性
Chem Pharm Bull (Tokyo). 1997 Jul;45(7):1169-76. doi: 10.1248/cpb.45.1169.
5
Synthesis and antifungal activity of novel thiazole-containing triazole antifungals. II. Optically active ER-30346 and its derivatives.新型含噻唑三唑类抗真菌剂的合成与抗真菌活性。II. 光学活性ER-30346及其衍生物。
Chem Pharm Bull (Tokyo). 1998 Apr;46(4):623-30. doi: 10.1248/cpb.46.623.
6
Synthesis and biological activities of some 3,6-disubstituted thiazolo[3,2-b][1,2,4]triazoles.一些3,6-二取代噻唑并[3,2-b][1,2,4]三唑的合成及生物活性
J Pharm Sci. 1995 Apr;84(4):462-5. doi: 10.1002/jps.2600840414.
7
Design, synthesis, and in vitro evaluation of novel antifungal triazoles.新型抗真菌三唑类化合物的设计、合成及体外评价
Bioorg Med Chem Lett. 2017 May 15;27(10):2171-2173. doi: 10.1016/j.bmcl.2017.03.062. Epub 2017 Mar 23.
8
Synthesis and SAR studies of biaryloxy-substituted triazoles as antifungal agents.作为抗真菌剂的联苯氧基取代三唑类化合物的合成及构效关系研究
Bioorg Med Chem Lett. 2008 Jun 1;18(11):3261-5. doi: 10.1016/j.bmcl.2008.04.056. Epub 2008 Apr 25.
9
Synthesis of novel thiazolo[4,5-d]pyrimidine derivatives for antimicrobial, anti-HIV and anticancer investigation.新型噻唑并[4,5-d]嘧啶衍生物的合成用于抗菌、抗HIV及抗癌研究。
Pharmazie. 1996 Dec;51(12):927-31.
10
Synthesis and biological investigations of some novel thiazolylbenzimidazoles, and benzimidazolyl-thiazolo[4,5-d]pyrimidines.一些新型噻唑基苯并咪唑及苯并咪唑基噻唑并[4,5-d]嘧啶的合成与生物学研究
Pharmazie. 1997 May;52(5):346-50.

引用本文的文献

1
Synthesis and Antifungal Activity of 1,2,4-Oxadiazole Derivatives.1,2,4-恶二唑衍生物的合成及其抗真菌活性
Molecules. 2025 Apr 20;30(8):1851. doi: 10.3390/molecules30081851.
2
An updated review on 1,2,3-/1,2,4-triazoles: synthesis and diverse range of biological potential.关于1,2,3-/1,2,4-三唑的最新综述：合成及其广泛的生物活性。
Mol Divers. 2025 Feb;29(1):899-964. doi: 10.1007/s11030-024-10858-0. Epub 2024 Jul 27.
3
Heterocycles 52: The Drug-Likeness Analysis of Anti-Inflammatory Thiazolo[3,2-b][1,2,4]triazole and Imidazo[2,1-b][1,3,4]thiadiazole Derivatives.
杂环化合物52：抗炎噻唑并[3,2 - b][1,2,4]三唑和咪唑并[2,1 - b][1,3,4]噻二唑衍生物的类药性质分析
Pharmaceuticals (Basel). 2024 Feb 25;17(3):295. doi: 10.3390/ph17030295.
4
Transition-Metal Catalyzed Synthesis of Pyrimidines: Recent Advances, Mechanism, Scope and Future Perspectives.过渡金属催化嘧啶合成：最新进展、机理、范围和未来展望。
Top Curr Chem (Cham). 2024 Jan 31;382(1):4. doi: 10.1007/s41061-024-00451-2.
5
C-O Coupling of Hydrazones with Diacetyliminoxyl Radical Leading to Azo Oxime Ethers-Novel Antifungal Agents.腙与二乙酰亚胺基自由基的 C-O 偶联反应生成偶氮肟醚类化合物—新型抗真菌药物。
Molecules. 2023 Nov 30;28(23):7863. doi: 10.3390/molecules28237863.
6
Synthesis of amantadine clubbed -aryl amino thiazoles as potent urease, α-amylase & α-glucosidase inhibitors, kinetic and molecular docking studies.金刚烷胺连接芳基氨基噻唑类化合物作为强效脲酶、α-淀粉酶和α-葡萄糖苷酶抑制剂的合成、动力学及分子对接研究
RSC Adv. 2023 Aug 22;13(36):24988-25001. doi: 10.1039/d3ra05330j. eCollection 2023 Aug 21.
7
Permeability of New Antifungal Fluconazole Derivatives through a Lipophilic Membrane: Experiment and Modeling.新型抗真菌氟康唑衍生物通过亲脂性膜的渗透性：实验与建模。
Molecules. 2023 Jan 2;28(1):389. doi: 10.3390/molecules28010389.
8
Experimental Examination of Solubility and Lipophilicity as Pharmaceutically Relevant Points of Novel Bioactive Hybrid Compounds.新型生物活性杂合化合物的药学相关性质——溶解性和脂溶性的实验研究。
Molecules. 2022 Oct 1;27(19):6504. doi: 10.3390/molecules27196504.
9
Novel 1, 2, 4-Triazoles as Antifungal Agents.新型 1,2,4-三唑类抗真菌剂。
Biomed Res Int. 2022 Mar 22;2022:4584846. doi: 10.1155/2022/4584846. eCollection 2022.
10
Eco-friendly and regiospecific intramolecular cyclization reactions of cyano and carbonyl groups in N,N-disubstituted cyanamide.N,N-二取代氰基乙酰胺中氰基和羰基的环保、区域选择性分子内环化反应。
Mol Divers. 2022 Oct;26(5):2813-2823. doi: 10.1007/s11030-022-10401-z. Epub 2022 Feb 27.