基于峰度和偏度的高频磁场源成像癫痫灶的描绘。
Delineation of epileptogenic zones with high frequency magnetic source imaging based on kurtosis and skewness.
机构信息
MEG Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
MEG Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
出版信息
Epilepsy Res. 2021 May;172:106602. doi: 10.1016/j.eplepsyres.2021.106602. Epub 2021 Mar 8.
BACKGROUND
Neuromagnetic high frequency brain signals (HFBS, > 80 Hz) are a new biomarker for localization of epileptogenic zones (EZs) for pediatric epilepsy.
METHODS
Twenty three children with drug-resistant epilepsy and age/sex matched healthy controls were studied with magnetoencephalography (MEG). Epileptic HFBS in 80-250 Hz and 250-600 Hz were quantitatively determined by comparing with normative controls in terms of kurtosis and skewness. Magnetic sources of epileptic HFBS were localized and then compared to clinical EZs determined by invasive recordings and surgical outcomes.
RESULTS
Kurtosis and skewness of HFBS were significantly elevated in epilepsy patients compared to healthy controls (p < 0,001 and p < 0.0001, respectively). Sources of elevated MEG signals in comparison to normative data were co-localized to EZs for 22 (22/23, 96 %) patients.
CONCLUSIONS
The results indicate, for the first time, that epileptic HFBS can be noninvasively quantified by measuring kurtosis and skewness in MEG data. Magnetic source imaging based on kurtosis and skewness can accurately localize EZs.
SIGNIFICANCE
Source imaging of kurtosis and skewness of MEG HFBS provides a novel way for preoperative localization of EZs for epilepsy surgery.
背景
神经磁高频脑信号（HFBS，>80Hz）是一种新的生物标志物，可用于定位小儿癫痫的致痫区（EZs）。
方法
对 23 名耐药性癫痫儿童和年龄/性别匹配的健康对照组进行了脑磁图（MEG）研究。通过与正常对照比较峰度和偏度，定量确定 80-250Hz 和 250-600Hz 的癫痫性 HFBS。对癫痫性 HFBS 的磁源进行定位，并与通过侵入性记录和手术结果确定的临床 EZs 进行比较。
结果
与健康对照组相比，癫痫患者的 HFBS 峰度和偏度显著升高（p<0.001 和 p<0.0001）。与正常数据相比，MEG 信号升高的源与 22 名（22/23，96%）患者的 EZs 共定位。
结论
这些结果首次表明，通过测量 MEG 数据中的峰度和偏度，可以对癫痫性 HFBS 进行无创定量。基于峰度和偏度的磁源成像可以准确地定位 EZs。
意义
MEG HFBS 的峰度和偏度的源成像为癫痫手术的术前 EZs 定位提供了一种新方法。
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