Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, Qingdao 266101, China; Shandong Energy Institute, No. 189 Songling Road, Qingdao 266101, China; Qingdao New Energy Shandong Laboratory, No. 189 Songling Road, Qingdao 266101, China.
Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, Qingdao 266101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Curr Opin Biotechnol. 2021 Jun;69:273-280. doi: 10.1016/j.copbio.2021.02.004. Epub 2021 Mar 10.
Aspergillus terreus is an important Aspergillus species, which has been applied in the industrial production of the bio-based chemical itaconic acid and the lipid-lowering drug lovastatin. The excellent fermentation capability has been demonstrated in these industrial applications. The genomic information revealed that the outstanding capacity of natural product synthesis by A. terreus remains to be further explored. With advances of the genome mining strategy, the products of several cryptic biosynthetic gene clusters have been discovered recently. In addition, a series of metabolic engineering studies have been performed in the industrial strains of lovastatin and itaconic acid to further improve the production processes. This review presents the current progress and the future outlook in the field of A. terreus biotechnology.
土曲霉是一种重要的曲霉属真菌，已应用于生物基化学品衣康酸和降血脂药物洛伐他汀的工业生产。在这些工业应用中，其表现出了出色的发酵能力。基因组信息表明，土曲霉具有很强的天然产物合成能力，有待进一步探索。随着基因组挖掘策略的进步，最近发现了几个隐性生物合成基因簇的产物。此外，还在洛伐他汀和衣康酸的工业生产菌株中进行了一系列代谢工程研究，以进一步改进生产工艺。本文综述了土曲霉生物技术领域的最新进展和未来展望。
