Huang Xiaomei, Wang Yichao, Li Guangyu, Shao Zongze, Xia Jinmei, Qin Jiang-Jiang, Wang Weiyi
Department of Marine Biology, Xiamen Key Laboratory of Intelligent Fishery, Xiamen Ocean Vocational College, Xiamen, China.
Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen, China.
Front Microbiol. 2024 Feb 14;15:1361550. doi: 10.3389/fmicb.2024.1361550. eCollection 2024.
fungi are renowned for producing a diverse range of natural products with promising biological activities. These include lovastatin, itaconic acid, terrin, and geodin, known for their cholesterol-regulating, anti-inflammatory, antitumor, and antibiotic properties. In our current study, we isolated three dimeric nitrophenyl trans-epoxyamides (-), along with fifteen known compounds (-), from the culture of MCCC M28183, a deep-sea-derived fungus. The structures of compounds - were elucidated using a combination of NMR, MS, NMR calculation, and ECD calculation. Compound exhibited moderate inhibitory activity against human gastric cancer cells MKN28, while compound showed similar activity against MGC803 cells, with both showing IC values below 10 μM. Furthermore, compound exhibited moderate potency against ATCC 17802, with a minimum inhibitory concentration (MIC) value of 7.8 μg/mL. This promising research suggests potential avenues for developing new pharmaceuticals, particularly in targeting specific cancer cell lines and combating bacterial infections, leveraging the unique properties of these -derived compounds.
真菌以产生具有多种有前景生物活性的天然产物而闻名。这些产物包括洛伐他汀、衣康酸、特林和地菌素，它们分别具有调节胆固醇、抗炎、抗肿瘤和抗菌特性。在我们当前的研究中，我们从深海来源的真菌MCCC M28183的培养物中分离出了三种二聚体硝基苯基反式环氧酰胺（-）以及十五种已知化合物（-）。通过结合核磁共振（NMR）、质谱（MS）、NMR计算和电子圆二色光谱（ECD）计算确定了化合物-的结构。化合物对人胃癌细胞MKN28表现出中等抑制活性，而化合物对MGC803细胞表现出类似活性，两者的半数抑制浓度（IC）值均低于10μM。此外，化合物对ATCC 17802表现出中等效力，最低抑菌浓度（MIC）值为7.8μg/mL。这项有前景的研究为开发新药物指明了潜在途径，特别是利用这些衍生化合物的独特性质来靶向特定癌细胞系和对抗细菌感染。
