Department of Oncology, Hebei General Hospital, Shijiazhuang, Hebei, P.R. China.
Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou, Zhejiang, P.R. China.
Aging (Albany NY). 2021 Mar 10;13(6):8541-8562. doi: 10.18632/aging.202668.
Growing evidence has demonstrated that transforming acidic coiled-coil protein 3 (TACC3), a member of the TACC family, may be involved in regulating cell mitosis, transcription, and tumorigenesis. However, the role of TACC3 in kidney renal clear cell carcinoma (KIRC) remains unknown. In this study, multiple databases were used to determine the pattern of TACC3 in KIRC. We found that high TACC3 expression was associated with poor overall survival (OS) in stage I, II, IV and grade 3 KIRC patients. Univariate and multivariate Cox regression analyses showed that TACC3 was an independent risk factor for OS among KIRC patients. Moreover, TACC3 expression correlated with immune cell infiltration levels of B cells, T cells (CD8+, CD4+, follicular helper, regulatory and gamma delta), total and resting natural killer cells, total and activated dendritic cells, and resting mast cells. Furthermore, T cell exhaustion markers, such as PD1, CTLA4, LAG3 and TIM-3 were highly expressed in TACC3 overexpressing tissues. In addition, GSEA analysis revealed that the role of TACC3 in KIRC may be closely linked to immune-associated pathways. Therefore, our study reveals that TACC3 is a prognostic biomarker for OS among KIRC patients and may be associated with immune cell infiltration and T cell exhaustion.
越来越多的证据表明，转化酸性卷曲螺旋蛋白 3（TACC3）作为 TACC 家族的一员，可能参与调节细胞有丝分裂、转录和肿瘤发生。然而，TACC3 在肾透明细胞癌（KIRC）中的作用尚不清楚。在这项研究中，我们使用多个数据库来确定 TACC3 在 KIRC 中的表达模式。我们发现，TACC3 高表达与 I 期、II 期、IV 期和 3 级 KIRC 患者的总生存期（OS）不良相关。单因素和多因素 Cox 回归分析表明，TACC3 是 KIRC 患者 OS 的独立危险因素。此外，TACC3 表达与 B 细胞、T 细胞（CD8+、CD4+、滤泡辅助、调节和γδ）、总自然杀伤细胞和静息自然杀伤细胞、总树突状细胞和静息肥大细胞的免疫细胞浸润水平相关。此外，TACC3 过表达组织中高度表达了 T 细胞耗竭标志物，如 PD1、CTLA4、LAG3 和 TIM-3。此外，GSEA 分析表明，TACC3 在 KIRC 中的作用可能与免疫相关途径密切相关。因此，我们的研究表明，TACC3 是 KIRC 患者 OS 的预后生物标志物，可能与免疫细胞浸润和 T 细胞耗竭有关。
