Jinnah Sindh Medical University, Karachi, Pakistan.
Dow University of Health Sciences, Karachi, Pakistan.
Indian Heart J. 2021 Jan-Feb;73(1):22-25. doi: 10.1016/j.ihj.2020.11.008. Epub 2020 Nov 12.
Atrial fibrillation (AF) is characterized by abnormal heart rhythm. Among other well-known associations, recent studies suggest an association of AF with height. Height is related to 50 diseases spanning different body systems, AF is one of them. Since AF, a heterogeneous disease process, is influenced by structural, neural, electrical, and hemodynamic factors, height alters this process through its contribution to increasing atrial and ventricular size, leading to altered conduction patterns, autonomic dysregulation, and development of AF. Multiple underlying mechanisms associate height with AF. Apart from these indirect mechanisms, genome-wide association studies suggest the involvement of the same genes in AF and growth pathways. Tall stature is independently associated with a higher risk of AF development in healthy individuals. Since adult height is achieved much earlier than the onset of AF, protective measures can be taken in individuals with increased height to monitor, manage, and prevent the progression of AF.
心房颤动（AF）的特征是心律异常。最近的研究表明，除了其他众所周知的关联外，AF 还与身高有关。身高与跨越不同身体系统的 50 种疾病有关，AF 就是其中之一。由于 AF 是一种异质性疾病过程，受结构、神经、电和血流动力学因素的影响，身高通过增加心房和心室大小来改变这个过程，导致传导模式改变、自主神经失调和 AF 的发展。多种潜在机制将身高与 AF 联系在一起。除了这些间接机制外，全基因组关联研究表明，AF 和生长途径涉及相同的基因。在健康个体中，高身材与 AF 发展的风险增加独立相关。由于成年身高的形成远远早于 AF 的发病，因此可以对身高较高的个体采取保护措施进行监测、管理和预防 AF 的进展。
