1 Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
2 Sahlgrenska Academy, Health Metrics unit, Gothenburg, Sweden.
Eur J Prev Cardiol. 2018 Jan;25(2):173-180. doi: 10.1177/2047487317740644. Epub 2017 Nov 2.
Background A large body size in early adult life has been associated with an increased risk of atrial fibrillation (AF) later in life in men; however, this has not yet been investigated in women.
Prospective cohort study.
We included all women in the Swedish Medical Birth Registry with known weight and height from 1982 to 2014. The main exposure body surface area (BSA) was calculated as the square root of (height [cm] × weight [kg]/3600). Information on hospital diagnoses of AF were obtained from the Patient Registry. The study population comprised 1,522,329 women (mean age 28.3 years).
A total of 6993 women (0.5%) were diagnosed with AF during a maximum follow-up of 33.6 years (mean 16.6 years, confidence interval [CI] 16.6-16.6). Risk of AF rose linearly with increasing BSA, body mass index (BMI) and height, with up to a threefold increased risk in the biggest women. Hazard ratios associated with BSA were 1.21 (95% CI 1.12-1.30), 1.45 (95% CI 1.35-1.56) and 2.11 (95% CI 1.97-2.26) when comparing the second, third and fourth quartiles, respectively, with the first. The elevated risk persisted after stratifying for different levels of BMI, even among women with low-normal BMI. Conclusion A larger body size measured early in adulthood was, independent from BMI, associated with an increased risk of AF in women during follow-up of up to 33 years.
在成年早期，较大的体型与男性日后发生房颤（AF）的风险增加相关；然而，这在女性中尚未得到研究。
前瞻性队列研究。
我们纳入了 1982 年至 2014 年瑞典医疗出生登记处中所有已知体重和身高的女性。主要暴露体表面积（BSA）通过身高[cm]乘以体重[kg]除以 3600 的平方根计算。房颤的医院诊断信息从患者登记处获得。研究人群包括 1522329 名女性（平均年龄 28.3 岁）。
在最长 33.6 年（平均随访 16.6 年，置信区间 16.6-16.6）的随访中，共有 6993 名女性（0.5%）被诊断为房颤。房颤的风险与 BSA、体重指数（BMI）和身高呈线性增加，最大的女性风险增加了三倍。与 BSA 相关的风险比分别为 1.21（95%置信区间 1.12-1.30）、1.45（95%置信区间 1.35-1.56）和 2.11（95%置信区间 1.97-2.26），当分别比较第二、第三和第四四分位数与第一四分位时。即使在 BMI 处于低正常水平的女性中，这种风险升高也持续存在。
成年早期较大的体型与 BMI 无关，与女性在长达 33 年的随访期间发生房颤的风险增加相关。
