Mont Lluís, Tamborero David, Elosua Roberto, Molina Irma, Coll-Vinent Blanca, Sitges Marta, Vidal Bárbara, Scalise Andrea, Tejeira Alejandro, Berruezo Antonio, Brugada Josep
Thorax Institute, Hospital Clínic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, C/Villarroel 170, Barcelona, 08036 Catalonia, Spain.
Europace. 2008 Jan;10(1):15-20. doi: 10.1093/europace/eum263. Epub 2008 Jan 4.
The aetiology of atrial fibrillation (AF) remains unknown in some patients. The aim of the study was to identify new risk factors for developing lone AF (LAF).
A series of 107 consecutive patients younger than 65, seen in the emergency room for an episode of LAF of <48 h duration were included in the study. A group of 107 healthy volunteers matched for age and sex were recruited as controls. All subjects answered a validated questionnaire concerning leisure and occupational activities performed throughout their lifetimes to estimate accumulated hours of physical effort, classified in four levels of intensity. Demographic and echocardiographic measurements were also recorded. There were 69% of males and mean age was 48 +/- 11 years. AF was paroxysmal in 57% and persistent in the remaining 43%. Patients with AF performed more hours of both moderate and heavy intensity physical activity. They also were taller, and had a larger left atria, ventricle, and body surface area. At the multivariable analysis, only moderate and heavy physical activity, height, and anteroposterior atrial diameter were independently associated with LAF.
Accumulated lifetime physical activity, height, and left atrial size are risk factors for LAF in healthy middle-aged individuals.
部分心房颤动（AF）患者的病因仍不明。本研究旨在确定发生孤立性房颤（LAF）的新危险因素。
本研究纳入了107例连续的65岁以下患者，这些患者因持续时间小于48小时的LAF发作而在急诊室就诊。招募了107名年龄和性别匹配的健康志愿者作为对照。所有受试者均回答了一份经过验证的问卷，该问卷涉及他们一生中的休闲和职业活动，以估计累积的体力活动小时数，并分为四个强度级别。还记录了人口统计学和超声心动图测量数据。男性占69%，平均年龄为48±11岁。房颤为阵发性的占57%，持续性的占其余43%。房颤患者进行中度和高强度体力活动的时间更多。他们也更高，左心房、心室和体表面积更大。在多变量分析中，只有中度和高强度体力活动、身高和心房前后径与LAF独立相关。
在健康的中年个体中，终生累积体力活动、身高和左心房大小是LAF的危险因素。
