Department of Health Promotion System Sciences, Division of Health Sciences, Graduate School of Medicine, Osaka University.
Department of Clinical Thanatology and Geriatric Behavioral Science, Graduate School of Human Sciences, Osaka University.
Arch Gerontol Geriatr. 2021 Jul-Aug;95:104386. doi: 10.1016/j.archger.2021.104386. Epub 2021 Mar 4.
Physical function is a strong predictor of the adverse outcomes of cardiovascular disease in older populations. However, studies of healthy older people on the prevention of coronary heart disease (CHD) are very limited.
We prospectively examined the association of walking speed and handgrip strength with CHD in the community-dwelling older populations.
The study cohort in Japan included 1272 older people free from heart disease at the baseline. Physical function was identified based on walking speed and handgrip strength assessment at the survey site. Any new case of CHD was identified based on a self-reported doctor's diagnosis. Cox-proportion hazard models were adjusted for covariate factors to examine the CHD risk.
During the 7-year follow-up, 45 new cases of CHD (25 men and 20 women) were documented. Slow walking speed was strongly associated with CHD risk after adjusting for all confounding factors in the total participants and women (hazard ratio (HR)= 2.53, 95%confidence interval (CI), 1.20-5.33, p=0.015, and HR= 4.78, 95% CI,1.07-21.35, p=0.040, respectively), but not in men. Weak grip strength was associated with CHD after age-adjustment (HR= 2.45, 95%CI, 1.03-5.81, p=0.043) only in men. However, after additional multivariate adjustment, the associations were getting weaker.
身体机能是预测老年人群心血管疾病不良结局的一个强有力指标。然而，关于健康老年人预防冠心病（CHD）的研究非常有限。
我们前瞻性地研究了社区中老年人的步行速度和握力与 CHD 的相关性。
该研究队列包括日本的 1272 名无心脏病的老年人。在调查现场通过评估步行速度和握力来确定身体机能。根据自我报告的医生诊断确定任何新的 CHD 病例。Cox 比例风险模型调整了协变量因素，以检查 CHD 风险。
在 7 年的随访期间，记录了 45 例新的 CHD 病例（25 名男性和 20 名女性）。在总参与者和女性中，经过所有混杂因素调整后，缓慢的步行速度与 CHD 风险密切相关（风险比（HR）=2.53，95%置信区间（CI），1.20-5.33，p=0.015，和 HR=4.78，95%CI，1.07-21.35，p=0.040），但在男性中则不然。经过年龄调整后，握力弱与 CHD 相关（HR=2.45，95%CI，1.03-5.81，p=0.043），但仅在男性中。然而，在进一步的多变量调整后，关联变得较弱。
