Department of Nuclear Medicine, Graduate School of Medicine, Osaka City University, 1-4-3, Asahimachi, Abeno-ku, Osaka-City, Osaka-Fu 545-8585, Japan.
Department of Nuclear Medicine, Graduate School of Medicine, Osaka City University, 1-4-3, Asahimachi, Abeno-ku, Osaka-City, Osaka-Fu 545-8585, Japan.
Clin Imaging. 2021 Oct;78:14-18. doi: 10.1016/j.clinimag.2020.12.016. Epub 2021 Jan 4.
The incidence of bone metastases exceeds 85% in patients who die from prostate cancer. Bone scintigraphy is the most widely used method for the early detection of bone metastases in prostate cancer. We developed a software program that semi-automatically calculated the bone scan index (BSI) on technetium-99m hydroxymethylene diphosphonate bone scintigraphy scans with a computer-aided diagnosis system (CAD) and examined whether the BSI calculated using this software could replace the extent of disease (EOD) score.
The subjects were 175 patients who were diagnosed with prostate cancer at our hospital and underwent bone scintigraphy. We analyzed receiver operating characteristic curves to determine the BSI cutoff value between EOD groups. The cutoff value was determined based on the maximum value of the sum of the sensitivity and specificity.
BSI cutoff values of 0.20, 1.56, and 4.56 were used to distinguish between EOD 0 and 1-4 (sensitivity [87.2%] and specificity [100.0%]), between EOD 0- and 2-4 (sensitivity [85.2%] and specificity [92.0%]), and between EOD 0-2 and 3-4 (sensitivity [88.4%] and specificity [99.2%]), respectively.
Our results suggest that this software can calculate BSI, and the software may play a role in predicting prognosis and selecting an appropriate treatment strategy. If a sufficient number of other nuclear medicine tests are performed, creating a similar CAD system is possible.
在死于前列腺癌的患者中，骨转移的发生率超过 85%。骨闪烁扫描是前列腺癌骨转移早期检测最广泛使用的方法。我们开发了一种软件程序，可以在计算机辅助诊断系统（CAD）上对锝-99m 亚甲基二膦酸盐骨闪烁扫描进行半自动计算骨扫描指数（BSI），并检查该软件计算的 BSI 是否可以替代疾病程度（EOD）评分。
本研究对象为在我院诊断为前列腺癌并接受骨闪烁扫描的 175 例患者。我们分析了接收器操作特性曲线，以确定 EOD 组之间 BSI 的截止值。该截止值是基于灵敏度和特异性之和的最大值确定的。
使用 BSI 截止值 0.20、1.56 和 4.56 可区分 EOD 0 与 1-4（灵敏度[87.2%]和特异性[100.0%]）、EOD 0-2 与 2-4（灵敏度[85.2%]和特异性[92.0%]）以及 EOD 0-2 与 3-4（灵敏度[88.4%]和特异性[99.2%]）。
我们的结果表明，该软件可以计算 BSI，并且该软件可能在预测预后和选择适当的治疗策略方面发挥作用。如果进行足够数量的其他核医学检查，就有可能创建类似的 CAD 系统。
