一个用于评估 Tc-99m 羟甲基二膦酸盐骨扫描指数的计算机程序：使用 SPECT/CT 评估骨转移患者颌骨病变。
A computer program to assess the bone scan index for Tc-99m hydroxymethylene diphosphonate: evaluation of jaw pathologies of patients with bone metastases using SPECT/CT.
机构信息
Quantitative Diagnostic Imaging, Field of Oral and Maxillofacial Imaging and Histopathological Diagnostics, Course of Applied Science, The Nippon Dental University Graduate School of Life Dentistry at Niigata, Niigata, Japan.
Department of Oral and Maxillofacial Radiology, The Nippon Dental University School of Life Dentistry at Niigata, Niigata, Japan.
出版信息
Diagn Interv Radiol. 2023 Jan 31;29(1):190-194. doi: 10.5152/dir.2022.21999. Epub 2022 Nov 29.
PURPOSE
This study aimed to evaluate the jaw pathologies of patients with bone metastases using a computer program to assess the bone scan index (BSI) for Tc-99m hydroxymethylene diphosphonate (HMDP) with single-photon emission computed tomography/computed tomography (SPECT/CT).
METHODS
Ninety-seven patients with jaw pathologies (24 with bone metastases and 73 without) were evaluated. High-risk hot spots and BSI in the patients were evaluated using the VSBONE BSI (ver.1.1) analysis software for Tc-99m HMDP that scanned SPECT/CT and automatically defined the data. The two groups were compared using the Pearson chi-square test and Mann-Whitney U test for high-risk hot spots and BSI, respectively. A P value of <0.05 was considered statistically significant.
RESULTS
High-risk hot spot occurrence was significantly correlated to bone metastases [sensitivity, 21/24 (87.5%); specificity, 40/73 (54.8%); accuracy, 61/97 (62.9%); < 0.001]. The number of high-risk hot spots was higher in patients with bone metastases (5.96 ± 10.30) than in those without (0.90 ± 1.50; < 0.001). Furthermore, the BSI for patients with bone metastases (1.44 ± 2.18%) was significantly higher than for those without (0.22 ± 0.44%; < 0.001).
CONCLUSION
A computer program that assessed BSI for Tc-99m HMDP may be useful in the evaluation of patients with bone metastases using SPECT/CT.
目的
本研究旨在使用计算机程序评估 Tc-99m 羟甲基二膦酸盐（HMDP）骨扫描指数（BSI），通过单光子发射计算机断层扫描/计算机断层扫描（SPECT/CT）评估患有骨转移的患者的颌骨病变。
方法
评估了 97 例颌骨病变患者（24 例有骨转移，73 例无骨转移）。使用 VSBONE BSI（ver.1.1）分析软件评估 Tc-99m HMDP 的 SPECT/CT 扫描的高危热点和 BSI，并自动定义数据。分别使用 Pearson 卡方检验和 Mann-Whitney U 检验比较两组高危热点和 BSI。P 值<0.05 被认为具有统计学意义。
结果
高危热点的发生与骨转移显著相关[敏感度，21/24（87.5%）；特异性，40/73（54.8%）；准确性，61/97（62.9%）；<0.001]。有骨转移的患者高危热点数量（5.96±10.30）明显高于无骨转移的患者（0.90±1.50；<0.001）。此外，有骨转移的患者 BSI（1.44±2.18%）明显高于无骨转移的患者（0.22±0.44%；<0.001）。
结论
评估 Tc-99m HMDP 的 BSI 的计算机程序可能有助于通过 SPECT/CT 评估患有骨转移的患者。
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