• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Development of medical therapeutics in osteoarthritis: time for action to improve patient care.

作者信息

Sofat Nidhi, Watt Fiona E, Tan Ai Lyn

机构信息

Institute for Infection and Immunity, St George's, University of London, London, UK.

Department of Rheumatology, St George's, University Hospitals NHS Foundation Trust, London, UK.

出版信息

Rheumatology (Oxford). 2021 Aug 2;60(8):3487-3489. doi: 10.1093/rheumatology/keab263.

DOI:10.1093/rheumatology/keab263
PMID:33715006
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8328507/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/017c/8328507/c4238337c498/keab263f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/017c/8328507/c4238337c498/keab263f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/017c/8328507/c4238337c498/keab263f1.jpg

相似文献

1
Development of medical therapeutics in osteoarthritis: time for action to improve patient care.骨关节炎医学治疗方法的发展：是时候采取行动改善患者护理了。
Rheumatology (Oxford). 2021 Aug 2;60(8):3487-3489. doi: 10.1093/rheumatology/keab263.
2
Recent advances in intra-articular drug delivery systems for osteoarthritis therapy.近年来，用于骨关节炎治疗的关节内药物输送系统的研究进展。
Drug Discov Today. 2018 Oct;23(10):1761-1775. doi: 10.1016/j.drudis.2018.05.023. Epub 2018 May 21.
3
Candidates for Intra-Articular Administration Therapeutics and Therapies of Osteoarthritis.骨关节炎关节腔内给药治疗的候选药物与疗法
Int J Mol Sci. 2021 Mar 30;22(7):3594. doi: 10.3390/ijms22073594.
4
The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date.骨关节炎（DMOAD）治疗药物的研发：现有证据。
Drug Des Devel Ther. 2021 Jul 6;15:2921-2945. doi: 10.2147/DDDT.S295224. eCollection 2021.
5
FDA/Arthritis Foundation osteoarthritis drug development workshop recap: Assessment of long-term benefit.FDA/关节炎基金会骨关节炎药物研发研讨会纪要：长期获益评估。
Semin Arthritis Rheum. 2022 Oct;56:152070. doi: 10.1016/j.semarthrit.2022.152070. Epub 2022 Jul 14.
6
Therapeutic options in the selection of nonsteroidal, antiinflammatory drugs in the treatment of osteoarthritis: a review.骨关节炎治疗中选择非甾体抗炎药的治疗选择：综述
J Rheumatol. 1987 May;14 Spec No:94-7.
7
Animal Models of Osteoarthritis Part 1-Preclinical Small Animal Models: Challenges and Opportunities for Drug Development.骨关节炎的动物模型 第1部分——临床前小动物模型：药物开发面临的挑战与机遇
Curr Protoc. 2022 Nov;2(11):e596. doi: 10.1002/cpz1.596.
8
Chondroprotective Factors in Osteoarthritis: a Joint Affair.骨关节炎中的软骨保护因子：关节事务。
Curr Rheumatol Rep. 2019 Jun 21;21(8):41. doi: 10.1007/s11926-019-0840-y.
9
Future therapeutics for osteoarthritis.骨关节炎的未来治疗方法。
Bone. 2012 Aug;51(2):297-311. doi: 10.1016/j.bone.2011.10.008. Epub 2011 Oct 17.
10
Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis.基质金属蛋白酶 13 作为治疗骨关节炎有前景的靶点概述。
Int J Mol Sci. 2021 Feb 9;22(4):1742. doi: 10.3390/ijms22041742.

引用本文的文献

1
Osteoarthritis versus psoriasis arthritis: Physiopathology, cellular signaling, and therapeutic strategies.骨关节炎与银屑病关节炎：病理生理学、细胞信号传导及治疗策略。
Genes Dis. 2023 Jun 19;11(3):100986. doi: 10.1016/j.gendis.2023.04.021. eCollection 2024 May.
2
NOD2 attenuates osteoarthritis via reprogramming the activation of synovial macrophages.NOD2通过重新编程滑膜巨噬细胞的激活来减轻骨关节炎。
Arthritis Res Ther. 2023 Dec 20;25(1):249. doi: 10.1186/s13075-023-03230-4.
3
Aspirin reverses inflammatory suppression of chondrogenesis by stabilizing YAP.

本文引用的文献

1
Efficacy and safety of tanezumab administered as a fixed dosing regimen in patients with knee or hip osteoarthritis: a meta-analysis of randomized controlled phase III trials.固定剂量方案下注射用特立帕肽治疗膝骨关节炎或髋骨关节炎的疗效和安全性：一项随机对照 III 期临床试验的荟萃分析。
Clin Rheumatol. 2021 Jun;40(6):2155-2165. doi: 10.1007/s10067-020-05488-4. Epub 2020 Nov 6.
2
Risk factors for pain and functional impairment in people with knee and hip osteoarthritis: a systematic review and meta-analysis.膝关节和髋关节骨关节炎患者疼痛及功能障碍的危险因素：一项系统评价与荟萃分析
BMJ Open. 2020 Aug 7;10(8):e038720. doi: 10.1136/bmjopen-2020-038720.
3
阿司匹林通过稳定 YAP 逆转了炎症对软骨生成的抑制作用。
Cell Prolif. 2023 Apr;56(4):e13380. doi: 10.1111/cpr.13380. Epub 2022 Dec 10.
Effect of Tanezumab on Joint Pain, Physical Function, and Patient Global Assessment of Osteoarthritis Among Patients With Osteoarthritis of the Hip or Knee: A Randomized Clinical Trial.
替扎尼布治疗髋关节或膝关节骨关节炎患者的关节疼痛、身体功能和患者整体评估的疗效：一项随机临床试验。
JAMA. 2019 Jul 2;322(1):37-48. doi: 10.1001/jama.2019.8044.
4
Efficacy and potential determinants of exercise therapy in knee and hip osteoarthritis: A systematic review and meta-analysis.运动疗法治疗膝骨关节炎和髋骨关节炎的疗效和潜在决定因素：系统评价和荟萃分析。
Ann Phys Rehabil Med. 2019 Sep;62(5):356-365. doi: 10.1016/j.rehab.2019.04.006. Epub 2019 May 21.
5
Randomized, Double-Blind, Placebo-Controlled Trial of Intraarticular Trans-Capsaicin for Pain Associated With Osteoarthritis of the Knee.随机、双盲、安慰剂对照试验：关节内辣椒素治疗膝关节骨关节炎相关疼痛。
Arthritis Rheumatol. 2019 Sep;71(9):1524-1533. doi: 10.1002/art.40894. Epub 2019 Jul 17.
6
The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study.全球髋和膝关节骨关节炎负担：来自 2010 年全球疾病负担研究的估计。
Ann Rheum Dis. 2014 Jul;73(7):1323-30. doi: 10.1136/annrheumdis-2013-204763. Epub 2014 Feb 19.
7
Sensitivity and sensitisation in relation to pain severity in knee osteoarthritis: trait or state?膝关节骨关节炎中与疼痛严重程度相关的敏感性和致敏作用：特质还是状态？
Ann Rheum Dis. 2015 Apr;74(4):682-8. doi: 10.1136/annrheumdis-2013-204191. Epub 2013 Dec 18.
8
The epidemiology and impact of pain in osteoarthritis.骨关节炎疼痛的流行病学和影响。
Osteoarthritis Cartilage. 2013 Sep;21(9):1145-53. doi: 10.1016/j.joca.2013.03.018.
9
A double-blind, randomized, placebo-controlled study of the efficacy and safety of duloxetine for the treatment of chronic pain due to osteoarthritis of the knee.一项关于度洛西汀治疗膝骨关节炎慢性疼痛的疗效和安全性的双盲、随机、安慰剂对照研究。
Pain Pract. 2011 Jan-Feb;11(1):33-41. doi: 10.1111/j.1533-2500.2010.00401.x.
10
Understanding the pain experience in hip and knee osteoarthritis--an OARSI/OMERACT initiative.了解髋膝关节骨关节炎的疼痛体验——一项骨关节炎研究学会/国际骨关节炎研究学会协作组计划
Osteoarthritis Cartilage. 2008 Apr;16(4):415-22. doi: 10.1016/j.joca.2007.12.017. Epub 2008 Mar 4.