Sports Nutrition and Performance Research Group, Department of Sport and Physical Activity, Edge Hill University, Ormskirk, UK.
Applied Physiology and Nutrition Research Group, School of Physical Education and Sport; Rheumatology Division; Faculdade De Medicina FMUSP, Universidade De Sao Paulo, Sao Paulo, SP, BR, University of São Paulo, SP, Brazil.
Res Sports Med. 2021 Nov-Dec;29(6):505-516. doi: 10.1080/15438627.2021.1896517. Epub 2021 Mar 9.
To compare the bicarbonate kinetics and gastrointestinal (GI) symptom responses between an equal dose of sodium bicarbonate and sodium citrate using delayed-release capsules. Thirteen active males (age 20.5 ± 2.1 y, height 1.8 ± 0.1 m and body mass [BM] 76.5 ± 9.6 kg) consumed either 0.3 gkg BM sodium bicarbonate, sodium citrate or a placebo, using a double-blind, randomized crossover design. Blood bicarbonate ion (HCO) concentration, pH and GI symptoms were measured pre-consumption and every 10 min for 180 min post-consumption. Blood HCO concentration ( < 0.001) and pH ( = 0.040) were significantly higher in the sodium bicarbonate condition compared with sodium citrate condition up to 3 h post-consumption. Peak blood HCO concentration was significantly higher with the sodium bicarbonate compared with citrate ( < 0.001). Mean GI symptom scores were lower ( = 0.037) for sodium citrate (1.5 ± 1.8 AU) than bicarbonate (2.6 ± 3.1 AU), with considerable inter-individual variability. No GI symptoms were reported following consumption of the placebo. Both substances increase HCO values significantly, with sodium bicarbonate causing significantly higher pH and HCO values than the same dose of sodium citrate, but results in slightly more severe GI symptoms.
比较使用延迟释放胶囊的等量碳酸氢钠和柠檬酸钠的碳酸氢盐动力学和胃肠道 (GI) 症状反应。13 名活跃男性（年龄 20.5±2.1 岁，身高 1.8±0.1 米，体重 [BM]76.5±9.6 公斤）使用双盲、随机交叉设计，分别摄入 0.3gkg BM 碳酸氢钠、柠檬酸钠或安慰剂。在摄入前和摄入后 180 分钟内，每 10 分钟测量一次血液碳酸氢根离子 (HCO) 浓度、pH 值和胃肠道症状。与柠檬酸钠条件相比，碳酸氢钠条件下血液 HCO 浓度（<0.001）和 pH 值（=0.040）在摄入后 3 小时内显著升高。与柠檬酸钠相比，碳酸氢钠的血液 HCO 峰值浓度显著升高（<0.001）。与碳酸氢钠（2.6±3.1 AU）相比，柠檬酸钠（1.5±1.8 AU）的平均胃肠道症状评分较低（=0.037），个体间差异较大。摄入安慰剂后没有报告胃肠道症状。两种物质均显著增加 HCO 值，碳酸氢钠引起的 pH 和 HCO 值明显高于相同剂量的柠檬酸钠，但胃肠道症状略严重。
