The Interdisciplinary Program of the Innovative Manufacturing Engineering, Pusan National University, Busan, 46241, Republic of Korea.
Electronic Convergence Division, Korea Institute of Ceramic Engineering & Technology, Jinju, 52851, Republic of Korea.
J Nanosci Nanotechnol. 2021 Jul 1;21(7):3651-3655. doi: 10.1166/jnn.2021.19167.
A formulation for controlled delivery of ibuprofen (IBU) involving montmorillonite (MMT) nanoclays has been proposed. The present work has investigated the beneficial effect of MMT in improving controlled delivery of IBU. The intercalation of IBU into the interlayer of MMT was studied under different processing conditions such as reaction time and initial concentration of IBU. To characterize the IBU/MMT composites, X-ray diffraction (XRD) and Fourier transform infrared spectra (FTIR) were performed. The release behavior of IBU from IBU/MMT composites have been investigated under vitro conditions using buffer media of simulated gastric fluid (pH 1.2) and simulated intestinal fluid (pH 7.4) at 37 °C. Controlled release of IBU from IBU/MMT composite has been observed during release experiments. Different mathematical models were used for fitting our experimental results, among them the best fitting was found for Higuchi equation based on the parabolic diffusion process.
已经提出了一种涉及蒙脱土（MMT）纳米粘土的布洛芬（IBU）控制释放配方。本工作研究了 MMT 在改善 IBU 控制释放中的有益作用。在不同的处理条件下，如反应时间和 IBU 的初始浓度，研究了 IBU 插入 MMT 层间的情况。为了表征 IBU/MMT 复合材料，进行了 X 射线衍射（XRD）和傅里叶变换红外光谱（FTIR）。在 37°C 下，使用模拟胃液（pH 1.2）和模拟肠液（pH 7.4）的缓冲介质，在体外条件下研究了 IBU 从 IBU/MMT 复合材料中的释放行为。在释放实验过程中观察到 IBU 从 IBU/MMT 复合材料中的控制释放。使用不同的数学模型对我们的实验结果进行拟合，其中根据抛物线扩散过程，发现基于 Higuchi 方程的拟合效果最好。
