Meyer Aaron M, Snider Sarah F, McGowan Shelby A, Tippett Donna C, Hillis Argye E, Friedman Rhonda B
Center for Aphasia Research and Rehabilitation, Georgetown University Medical Center.
Department of Neurology, Johns Hopkins University.
Aphasiology. 2020;34(6):664-674. doi: 10.1080/02687038.2020.1734527. Epub 2020 Mar 3.
Findings from several studies have indicated that participants with nfvPPA and participants with svPPA exhibit different patterns on action and object naming tasks, while other recent studies have found that neither participants with nfvPPA nor participants with svPPA show a significant difference in accuracy between object naming and action naming.
The goal of this study was to test the hypothesis that relative action naming impairment is associated with grammatical ability in PPA, rather than a specific subtype of PPA.
METHODS & PROCEDURES: Thirty-four participants with PPA completed the Boston Naming Test, the Action Naming subtest of the Boston Diagnostic Aphasia Examination, and the Northwestern Anagram Test, which was used to measure grammatical ability. -scores for the two naming tasks were calculated based on normative data from unimpaired controls. For each participant with PPA, the relative action naming impairment was calculated by subtracting the object naming -score from the action naming -score. Linear regression analysis was then used to evaluate the role of grammatical ability as a predictor of relative action naming impairment, while controlling for age, education, cognitive ability (as measured by the Montreal Cognitive Assessment), and semantic ability (as measured by the Pyramids and Palm Trees test). The interaction between grammatical ability and each control variable was also examined.
OUTCOMES & RESULTS: The main effect of grammatical ability was a significant predictor of relative action naming impairment, while none of the control variables was a significant predictor. However, the interaction between grammatical ability and semantic ability was also significant.
Individuals who have both grammatical impairment and semantic impairment have the largest relative action naming impairment. These individuals may benefit from a treatment that focuses on the retrieval of verbs and their arguments.
多项研究结果表明，非流利性原发性进行性失语（nfvPPA）患者和流利性原发性进行性失语（svPPA）患者在动作命名和物体命名任务中表现出不同模式，而最近的其他研究发现，nfvPPA患者和svPPA患者在物体命名和动作命名的准确性上均无显著差异。
本研究的目的是检验以下假设：相对动作命名障碍与原发性进行性失语（PPA）中的语法能力相关，而非与PPA的特定亚型相关。
34名PPA患者完成了波士顿命名测试、波士顿诊断性失语检查的动作命名子测试以及用于测量语法能力的西北字谜测试。根据未受损对照组的标准数据计算两项命名任务的得分。对于每位PPA患者，通过用动作命名得分减去物体命名得分来计算相对动作命名障碍。然后使用线性回归分析来评估语法能力作为相对动作命名障碍预测指标的作用，同时控制年龄、教育程度、认知能力（通过蒙特利尔认知评估测量）和语义能力（通过金字塔和棕榈树测试测量）。还检查了语法能力与每个控制变量之间的相互作用。
语法能力的主效应是相对动作命名障碍的显著预测指标，而没有一个控制变量是显著预测指标。然而，语法能力和语义能力之间的相互作用也很显著。
同时患有语法障碍和语义障碍的个体相对动作命名障碍最大。这些个体可能受益于专注于动词及其论据提取的治疗方法。
