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两个与脱氧胸苷三磷酸合成相关的基因调控烟粉虱MED中专性共生菌的密度和繁殖。

Two Deoxythymidine Triphosphate Synthesis-Related Genes Regulate Obligate Symbiont Density and Reproduction in the Whitefly MED.

作者信息

Yang Zezhong, Gong Cheng, Hu Yuan, Zhong Jie, Xia Jixing, Xie Wen, Yang Xin, Guo Zhaojiang, Wang Shaoli, Wu Qingjun, Zhang Youjun

机构信息

Department of Plant Protection, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, China.

出版信息

Front Physiol. 2021 Feb 24;11:574749. doi: 10.3389/fphys.2020.574749. eCollection 2020.

DOI:10.3389/fphys.2020.574749
PMID:33716755
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7943623/
Abstract

Deoxythymidine triphosphate (dTTP) is essential for DNA synthesis and cellular growth in all organisms. Here, genetic capacity analysis of the pyrimidine pathway in insects and their symbionts revealed that dTTP is a kind of metabolic input in several host insect/obligate symbiont symbiosis systems, including MED/ (hereafter ). As such, the roles of dTTP on both sides of the symbiosis system were investigated in MED/. Dietary RNA interference (RNAi) showed that suppressing dTTP production significantly reduced the density of , significantly repressed the expression levels of horizontally transferred essential amino acid (EAA) synthesis-related genes, and significantly decreased the reproduction of MED adults as well as the hatchability of their offspring. Our results revealed the regulatory role of dTTP in MED/ and showed that dTTP synthesis-related genes could be potential targets for controlling as well as other sucking pests.

摘要

脱氧胸苷三磷酸（dTTP）对于所有生物体的DNA合成和细胞生长至关重要。在此，对昆虫及其共生体中嘧啶途径的遗传能力分析表明，dTTP是几种宿主昆虫/专性共生体共生系统中的一种代谢输入物，包括MED/（以下简称）。因此，在MED/中研究了dTTP在共生系统双方的作用。饮食RNA干扰（RNAi）表明，抑制dTTP的产生显著降低了的密度，显著抑制了水平转移的必需氨基酸（EAA）合成相关基因的表达水平，并显著降低了MED成虫的繁殖力及其后代的孵化率。我们的结果揭示了dTTP在MED/中的调节作用，并表明dTTP合成相关基因可能是控制以及其他刺吸式害虫的潜在靶标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef9a/7943623/bb3dee99b024/fphys-11-574749-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef9a/7943623/bb3dee99b024/fphys-11-574749-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef9a/7943623/57c8d442ae5a/fphys-11-574749-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef9a/7943623/cca9cd69460a/fphys-11-574749-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef9a/7943623/c53c9ec9c800/fphys-11-574749-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef9a/7943623/25510fff621e/fphys-11-574749-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef9a/7943623/bb3dee99b024/fphys-11-574749-g006.jpg

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