Thompson Aiysha, da Fonseca Diogo M, Walker Louise, Griffiths James S, Taylor Philip R, Gow Neil A R, Orr Selinda J
Division of Infection and Immunity, Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, United Kingdom.
UK Dementia Research Institute, Cardiff, United Kingdom.
Front Microbiol. 2021 Feb 25;12:633229. doi: 10.3389/fmicb.2021.633229. eCollection 2021.
More than 95% of invasive infections are caused by four spp. (). C-type lectin-like receptors (CLRs), such as Dectin-1, Dectin-2, and Mincle mediate immune responses to . Dectin-1 promotes clearance of , and , however, dependence on Dectin-1 for specific immune responses varies with the different spp. Dectin-2 is important for host immunity to and , and Mincle is important for the immune response to However, whether Dectin-2 drives host immunity to or , and whether Mincle mediates host immunity to or is unknown. Therefore, we compared the roles of Dectin-2 and Mincle in response to these four spp. We demonstrate that these four spp. cell walls have differential mannan contents. Mincle and Dectin-2 play a key role in regulating cytokine production in response to these four spp. and Dectin-2 is also important for clearance of all four spp. during systemic infection. However, Mincle was only important for clearance of during systemic infection. Our data indicate that multiple spp. have different mannan contents, and dependence on the mannan-detecting CLRs, Mincle, and Dectin-2 varies between different spp. during systemic infection.
超过95%的侵袭性感染由四种菌属（ ）引起。C型凝集素样受体（CLRs），如Dectin-1、Dectin-2和Mincle介导对 的免疫反应。Dectin-1促进对 以及 的清除，然而，对特定免疫反应对Dectin-1的依赖性因不同的菌属而异。Dectin-2对宿主抵抗 和 的免疫很重要，而Mincle对 的免疫反应很重要。然而，Dectin-2是否驱动宿主对 或 的免疫，以及Mincle是否介导宿主对 或 的免疫尚不清楚。因此，我们比较了Dectin-2和Mincle在对这四种菌属反应中的作用。我们证明这四种菌属的细胞壁甘露聚糖含量不同。Mincle和Dectin-2在调节对这四种菌属反应中的细胞因子产生中起关键作用，并且Dectin-2在全身感染期间对清除所有四种菌属也很重要。然而，Mincle仅在全身感染期间对 的清除很重要。我们的数据表明多种菌属具有不同的甘露聚糖含量，并且在全身感染期间，不同菌属对检测甘露聚糖的CLRs、Mincle和Dectin-2的依赖性有所不同。
