Babik J M, Katrak S, Miller S, Shah M, Chin-Hong P
Division of Infectious Diseases, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.
Transpl Infect Dis. 2015 Oct;17(5):744-50. doi: 10.1111/tid.12431. Epub 2015 Sep 26.
Epstein-Barr virus (EBV) encephalitis has been infrequently described in immunocompromised patients. Here, we report a unique case of biopsy-proven EBV encephalitis in a renal transplant recipient presenting with altered mental status, prominent visual disturbances, and hemorrhagic, ring-enhancing mass lesions on magnetic resonance imaging. The patient was successfully treated with a prolonged course of antivirals. This case illustrates the difficulty in interpretation of cerebrospinal fluid EBV polymerase chain reaction assay, given the lack of specificity in immunocompromised patients.
爱泼斯坦-巴尔病毒（EBV）脑炎在免疫功能低下的患者中鲜有报道。在此，我们报告一例经活检证实的肾移植受者EBV脑炎病例，该患者表现为精神状态改变、明显的视觉障碍，磁共振成像显示有出血性、环形强化的肿块病变。患者通过长期抗病毒治疗成功治愈。鉴于免疫功能低下患者缺乏特异性，该病例说明了脑脊液EBV聚合酶链反应检测结果解释的困难性。
