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微小RNA-432-5p通过靶向趋化因子配体5抑制结直肠癌细胞的迁移和侵袭。

MicroRNA-432-5p inhibits cell migration and invasion by targeting CXCL5 in colorectal cancer.

作者信息

Luo Man, Hu Zuowei, Kong Yuefeng, Li Lingyi

机构信息

Department of Oncology, Wuhan No. 1 Hospital, Wuhan, Hubei 430022, P.R. China.

Department of Radiology, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.

出版信息

Exp Ther Med. 2021 Apr;21(4):301. doi: 10.3892/etm.2021.9732. Epub 2021 Jan 29.

DOI:10.3892/etm.2021.9732
PMID:33717244
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7885074/
Abstract

MicroRNAs (miRNAs) play an important role in the occurrence and development of colorectal cancer (CRC). Evidence shows that miR-432-5p expression is decreased in various tumors and cancer cell lines. miR-432-5p can inhibit tumor invasion and metastasis, but its role in colorectal cancer is unclear. The present study demonstrated that miR-432-5p expression was decreased in colorectal cancer tissue and cell lines, and is negatively associated with invasion classification, lymph node metastasis and Tumor-Node-Metastasis stage. Kaplan-Meier survival analysis showed that low miR-432-5p expression was associated with a poor survival rate in patients with CRC. In addition, SW480 and HT-29 cells transfected with miR-432-5p mimics had decreased migration and invasion abilities, whereas miR-432-5p inhibitors had the opposite effect. The expression of C-X-C motif chemokine ligand 5 (CXCL5), a direct target of miR-432-5p, was negatively associated with miR-432-5p expression. When CXCL5 was introduced into miR-432-5p mimic-transfected SW480 and HT-29 cells, miR-432-5p-mediated inhibition of CRC migration and invasion was reversed. Thus, the present results suggest that miR-432-5p can inhibit the migration and invasion of CRC cells by targeting CXCL5.

摘要

微小RNA（miRNA）在结直肠癌（CRC）的发生和发展中起重要作用。证据表明，miR-432-5p在各种肿瘤和癌细胞系中的表达降低。miR-432-5p可抑制肿瘤侵袭和转移，但其在结直肠癌中的作用尚不清楚。本研究表明，miR-432-5p在结直肠癌组织和细胞系中的表达降低，且与侵袭分级、淋巴结转移和肿瘤-淋巴结-转移分期呈负相关。Kaplan-Meier生存分析表明，miR-432-5p低表达与CRC患者的低生存率相关。此外，用miR-432-5p模拟物转染的SW480和HT-29细胞的迁移和侵袭能力降低，而miR-432-5p抑制剂则有相反的效果。miR-432-5p的直接靶标C-X-C基序趋化因子配体5（CXCL5）的表达与miR-432-5p表达呈负相关。当将CXCL5导入miR-432-5p模拟物转染的SW480和HT-29细胞中时，miR-432-5p介导的对CRC迁移和侵袭的抑制作用被逆转。因此，本研究结果表明，miR-432-5p可通过靶向CXCL5抑制CRC细胞的迁移和侵袭。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba65/7885074/44007db56209/etm-21-04-09732-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba65/7885074/2776672e4dd8/etm-21-04-09732-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba65/7885074/38301983fa14/etm-21-04-09732-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba65/7885074/8e1675e28445/etm-21-04-09732-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba65/7885074/44007db56209/etm-21-04-09732-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba65/7885074/2776672e4dd8/etm-21-04-09732-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba65/7885074/38301983fa14/etm-21-04-09732-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba65/7885074/8e1675e28445/etm-21-04-09732-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba65/7885074/44007db56209/etm-21-04-09732-g03.jpg

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MicroRNA-432 Suppresses Invasion and Migration via E2F3 in Nasopharyngeal Carcinoma.微小RNA-432通过E2F3抑制鼻咽癌的侵袭和迁移。
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