Brookens Shawna K, Boothby Mark R
Cancer Biology Program, Vanderbilt University, Nashville, TN 37232, USA.
Department of Pathology-Microbiology-Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Immunometabolism. 2021;3(2). doi: 10.20900/immunometab20210011. Epub 2021 Feb 12.
A large and growing body of evidence supports functions of enzymes that regulate or effect cellular metabolism in governing the development, survival, and effector functions of immune cells-especially T cells, macrophages, and dendritic cells. Among these proteins, adenosine monophosphate-activated protein kinase (AMPK) is a conserved ATP and nutrient sensor that regulates multiple metabolic pathways to promote energy homeostasis. Although AMPK had been shown to regulate aspects of CD4 and CD8 T cell biology, its function in B lymphocytes has been less clear. Here, we review recent advances in our understanding of the role of AMPK in the metabolism, function, and maintenance of the B lineage.
调节或影响细胞代谢的酶在控制免疫细胞（尤其是T细胞、巨噬细胞和树突状细胞）的发育、存活和效应功能方面发挥作用。在这些蛋白质中，腺苷单磷酸激活的蛋白激酶（AMPK）是一种保守的ATP和营养传感器，可调节多种代谢途径以促进能量稳态。尽管已证明AMPK可调节CD4和CD8 T细胞生物学的多个方面，但其在B淋巴细胞中的功能尚不清楚。在此，我们综述了近年来对AMPK在B细胞系的代谢、功能和维持中的作用的理解进展。
