Cao Yingshu, Di Xin, Zhang Qinghua, Li Ranwei, Wang Ke
Department of Respiratory Medicine, The Second Hospital of Jilin University, Changchun, China.
Department of Urinary Surgery, The Second Hospital of Jilin University, Changchun, China.
Front Oncol. 2021 Feb 24;11:603932. doi: 10.3389/fonc.2021.603932. eCollection 2021.
The RNA-binding motif protein 10 (RBM10) is involved in alternative splicing and modifies mRNA post-transcriptionally. RBM10 is abnormally expressed in the lung, breast, and colorectal cancer, female genital tumors, osteosarcoma, and other malignant tumors. It can inhibit proliferation, promote apoptosis, and inhibit invasion and metastasis. RBM10 has long been considered a tumor suppressor because it promotes apoptosis through the regulation of the MDM2-p53 negative feedback loop, Bcl-2, Bax, and other apoptotic proteins and inhibits proliferation through the Notch signaling and rap1a/Akt/CREB pathways. However, it has been recently demonstrated that RBM10 can also promote cancer. Given these different views, it is necessary to summarize the research progress of RBM10 in various fields to reasonably analyze the underlying molecular mechanisms, and provide new ideas and directions for the clinical research of RBM10 in various cancer types. In this review, we provide a new perspective on the reasons for these opposing effects on cancer biology, molecular mechanisms, research progress, and clinical value of RBM10.
RNA结合基序蛋白10（RBM10）参与可变剪接，并在转录后修饰mRNA。RBM10在肺癌、乳腺癌、结直肠癌、女性生殖系统肿瘤、骨肉瘤和其他恶性肿瘤中异常表达。它可以抑制增殖、促进凋亡，并抑制侵袭和转移。长期以来，RBM10一直被认为是一种肿瘤抑制因子，因为它通过调节MDM2-p53负反馈回路、Bcl-2、Bax和其他凋亡蛋白来促进凋亡，并通过Notch信号通路和rap1a/Akt/CREB通路抑制增殖。然而，最近有研究表明RBM10也可以促进癌症发生。鉴于这些不同的观点，有必要总结RBM10在各个领域的研究进展，以合理分析其潜在的分子机制，并为RBM10在各种癌症类型中的临床研究提供新的思路和方向。在这篇综述中，我们对RBM10在癌症生物学中这些相反作用的原因、分子机制、研究进展和临床价值提供了新的视角。
