Zhang Qihe, Wang Huanhuan, Zhao Qin, Zhang Yuyu, Zheng Zhuangzhuang, Liu Shiyu, Liu Zijing, Meng Lingbin, Xin Ying, Jiang Xin
Department of Radiation Oncology, The First Hospital of Jilin University, Changchun, China.
Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University, Changchun, China.
Front Oncol. 2021 Feb 25;11:606010. doi: 10.3389/fonc.2021.606010. eCollection 2021.
The survival rate of patients with laryngeal squamous cell carcinoma (LSCC) is correlated with several factors. However, the independent prognostic factors of patients with LSCC remain unclear. Thus, we sought to identify prognostic factors affecting LSCC outcomes in the Chinese population.
The survival and potential prognostic factors of 211 patients with LSCC between April 2011 and July 2019 were retrospectively analyzed. Overall survival (OS) and progression free survival (PFS) were estimated by the Kaplan Meier method, and a log-rank test was used to compare the possible prognostic factors between different groups. The Cox proportional hazard model was used to perform multivariable analysis of significant covariants.
A total of 211 LSCC patients were included, of which 164 (77.7%) were male and 47 (22.3%) were female. Mean age was 62.19 ± 8.328 years. A univariate analysis showed that seven factors including pathological differentiation, clinical stage, tobacco consumption, alcohol consumption, T stage, N stage, and concurrent chemoradiotherapy were correlated with survival (<0.05). Cox proportional hazards regression analyses revealed that clinic stage (hazard ratio=3.100, p=0.048), pathological differentiation (hazard ratio = 2.538, p=0.015), alcohol consumption (hazard ratio = 8.456, p =0.004) were associated with OS in LSCC. Pathological differentiation (hazard ratio =5.677, p=0.000), alcohol consumption (hazard ratio =6.766, p=0.000) were associated with PFS in LSCC.
Pathological differentiation, alcohol consumption, are independent prognostic factors and predictors of recurrence in LSCC. These factors could help inform guidelines for clinical treatment and prognosis.
喉鳞状细胞癌（LSCC）患者的生存率与多种因素相关。然而，LSCC患者的独立预后因素仍不清楚。因此，我们试图在中国人群中确定影响LSCC预后的因素。
回顾性分析2011年4月至2019年7月期间211例LSCC患者的生存情况及潜在预后因素。采用Kaplan-Meier法估计总生存期（OS）和无进展生存期（PFS），并使用对数秩检验比较不同组之间可能的预后因素。采用Cox比例风险模型对显著协变量进行多变量分析。
共纳入211例LSCC患者，其中男性164例（77.7%），女性47例（22.3%）。平均年龄为62.19±8.328岁。单因素分析显示，病理分化、临床分期、吸烟、饮酒、T分期、N分期和同步放化疗7个因素与生存率相关（<0.05）。Cox比例风险回归分析显示，临床分期（风险比=3.100，p=0.048）、病理分化（风险比=2.538，p=0.015）、饮酒（风险比=8.456，p=0.004）与LSCC的OS相关。病理分化（风险比=5.677，p=0.000）、饮酒（风险比=6.766，p=0.000）与LSCC的PFS相关。
病理分化、饮酒是LSCC的独立预后因素和复发预测因素。这些因素有助于为临床治疗和预后指南提供参考。
